Muscarinic Antagonists Flashcards
Atropine
Eye: produce mydriasis and cycloplegia (block M3)
Airway: decrease secretions
Stomach: decrease acid secretion
Gut: decrease motility
Bladder: decreased urgency in cystitis
*Blocks DUMBBeLSS in cholinesterase inhibitor poisoning
Homatropine
Works in eye
Produce mydriasis and cycloplegia (M3)
Tropicamide
Works in eye
Produce mydriasis and cycloplegia (M3)
Benztropine
Works in CNS
Used in Parkinson disease and acute dystonia
Trihexyphenidyl
Works in CNS
Used in Parkinson disease and acute dystonia
Glycopyrrolate
Works in GI, respiratory
Parenteral: preoperative use to reduce airway secretions
Oral uses: drooling, peptic ulcer
Hyoscyamine
Works in GI
Use: antispasmodic for IBS
Dicyclomine
Works in GI
Use: antispasmodic for IBS
Ipratropium
Works in respiratory
Use: COPD, asthma (M3)
Tiotropium
Works in respiratory
Use: COPD, asthma (M3)
Oxybutynin
Works in GU
Use: reduce bladder spasms and urge urinary incontinence (overactive bladder)
Solifenacin
Works in GU
Use: reduce bladder spasms and urge urinary incontinence (overactive bladder)
Tolterodine
Works in GU
Use: reduce bladder spasms and urge urinary incontinence (overactive bladder)
Scopolamine
Works in CNS
Use: motion sickness (M1)
Atropine adverse effects
Hot as a hare–increased body temperature (decreased sweating)
Dry as a bone–dry mouth, dry skin
Red as a beet–flushed skin
Blind as a bat–cycloplegia
Mad as a hatter–disorientation
*Also causes constipation
*Can = acute angle-closure glaucoma in elderly (mydriasis), urinary retention in men with BPH, and hyperthermia in infants
