Concepts in rheumatology Flashcards
what are the two main categories of arthritis?
Non-inflammatory arthritis (commonly osteoarthritis)
Inflammatory arthritis
What can inflammatory arthritis be further subdivided into?
Seropositive (autoantibodies in serum):
- RA
- lupus
- Scleroderma
- Vasculitis
- Sjogrens
Seronegative:
- Ankylosing spondylitis
- Psoriatic arthritis
- Reactive arthritis
- Inflammatory bowel disease arthritis
- infectious
- crystal induced
What is the assoc condition with anti-CCP antibody?
-rheumatoid arthritis
What are the assoc condition with anti-nuclear antibody?
SLE, Sjogrens syndrome, Systemic sclerosis, MCTD, autoimmune liver disease`
What antibodies are found in SLE?
- Anti-dsDNA abody
- Anti-Sm
- Anti-Ro
- Anti-RNP
What are the antibodies found in sjogrens syndrome?
- Anti-ro
- Anti-la
What antibody is found in limited systemic sclerosis?
-anti-centromere antibody
What antibody is found in diffus systemic sclerosis?
-Anti-Scl-70 abody
What antibody is found in mixed connective tissue disease?
Anti-RNP antibody and ANA
What antibody is found in myositis?
Anti-Jo 1
What antibodies are found in anti-phospholipid syndrome?
- anti-cardiolipin antibody
- lupus anti-coagulant
What differentials are included with ANCA (anti-neutrophil cytoplasmic antibody)
small vessel vasculitis (GPA, EGPA, MPA)
What are the features of inflammatory conditions:
- joint pain/stiffness?
- systemic involvement?
- blood tests?
Joint pain – effect of activity
- Diurnal variation
Morning stiffness (>30mins)
Soft tissue swelling (synovitis)
May have other systems affected
May have inc. : PV/ESR/CRP
PV- plasma viscosity
ESR – erythrocyte sedimentation rate
CRP – c-reactive protein
What are the features of non-inflammatory conditions
- joint pain/stiffness
- systemic involvement?
- blood tests?
Mechanical pain – worse with activity
- no diurnal variation
No early morning stiffness
Generally localized (except fibromyalgia)
No systemic involvement
Normal blood tests
