miRNA Flashcards
miR-17-92
Represses RUNX1 which regulates colony stimulating factor receptor during monocytopoieses
miR-223
Promote monocyte and neutrophil differentiation
Represses myeloid ELF-like factor 2 to modulate neutrophil
miRNA-155
represses SHIP1 and CSFR to modulate myeloid cell differentiation
Represses expression of DC-SIGN
miR-34 and miR-21
Represses WNT1 and JAG1 to promote DC differentiation
How are miRNA involved in Cancer
Disregulation of miRNA is a hallmark of cancer
Upregulatuon of miRNA may act as oncogenes
Downregulated miRNA may be tumor suppressors
As if not more important than mutation to proteins in tumor development
miR-15a and mIR-16 are what and involved in which disease
Tumor suppressors that regulate bcl-2
Deleted in Chronic Lymphocytic Leukaemia
miR-29b does what and involved in what firsease
Tumor suppressor which represses specific DNA methyltransferases leading to global DNA hypomethylation and re-expressions of pro-apoptotic genes
What is miR 17-92
Can act as oncogene when overexpressed
Involved in Acute lymphoblastic leukaemia
Involved in Chronic myeloid leukaemia
miR-H2-3p
Herpesvirus miRNA from LAT pre-miRNA
Responsible for promoting latency
miRNA-K5
Targets BCALF1 (pro-apoptotic bcl2 protein) mRNA and targets for degradation inhibiting expression
mIR-let-7 in cancer
Loss of miR-let-7 enhances lung tumor formation
miR-let-7 is tumor suppressor
Synthetic let-7 shown effective in mouse models against lung tumor
miR-182 and cancer relation
Oncogenes
Overexpressed in melanoma
Us of miRNA sponge to reduce metastatic spread
miR-122 involvement in cancer
Abundant in liver and shown to stimulate HCV replication
Stabilises HCV genome by binding to 5’utr of genome unlike most which bind 3’UTR
Miravisen is miRNA sponge currently in phase 2 clinical trials
