B2.077 Cell Biology Collagen Flashcards
what are 3 functions of the basal lamina?
structure: anchors epithelium to basement membrane
sifting: barrier between blood and urine in glomerulus
signaling: present signaling molecules to the epithelium
what are the 6 primary components of connective tissue?
cells, extracellular matrix, supporting tissues, basement membranes, cartilage, bone
what makes up the extracellular matrix
fibers: collagen and elastin
ground substance: GAGs, protein core
what are the two subtypes of connective tissue?
proper: well organized
specialized
what are the 2 subtypes of proper connective tissue and their subsequent subtypes?
loose> areolar, adipose, or reticular
dense> regular, irregular, or elastic
what are the 3 subtypes of specialized connective tissue and their subtypes?
bone> spongy and compact
blood
cartilage>elastic, hyaline, fibrocartilage
which type of collagen is found in reticular tissue and is found in wound healing?
type 3
what collagen types primarily make up proper dense tissues?
1 & 2
what are the resident connective tissue cells?
fibroblasts (chondroblasts, osteoblasts, odontoblasts)
adipocytes
what are the transient connective tissue cells?
macrophages, plasma cells, mast cells, lymphocytes, eosinophils
what is the most abundant protein in the body?
collagen 1
what enzyme catalyzes the covalent linkage of collagen fibers?
lysyl oxidase
what cells secrete collagen?
fibroblasts
what type of collagen is found alongside type 1 but in smaller amounts?
type 5
what helps link collagen fibrils together in the fiber?
type 5 collagen
