Mechanisms Of Hypersensitivity Type III - Bowden (Completed)

Question 1

What kind of complexes are formed in type III hypersensitivity? 32

Answer 1

Soluble immune complexes formed in circulation

Question 2

What is the problem in Type III Hypersensitivities? 32

Answer 2

circulating soluble immune complexes are not removed by the normal waste system and are instead deposited into tissue

larger the size the bigger the problem

Question 3

Do a walkthrough of Type III Hypersensitivities. 34

Answer 3

inflamed immune complexes induce basophils and platelets to release vasoactive amines (histamine)

histamine causes increased vascular permability

leads to complex deposition

increased deposition causes C’ act. and platelet aggregation

microthrombi form, neutrophils attracted and cause damage

Question 4

What are some diseases associated with Type III Hypersensitivity? 35

Answer 4

SLE - nephritis, arthritis, vasculitis

Serum Sickness - system vasculitis, nephritis, arthritis

Arthur’s reaction - cutaneous vasculitis

Polyarteritis Nodosa - vasculitis

Question 5

What are the differences between Type II & III Hypersensitivity? 36

Answer 5

Type II - fixed Ag

Type III - soluble Ag

Complement is a major mediator of both

Question 6

What are the four broad clinical manifestations associated with type III hypersensitivities? 32

Answer 6

Fever

Arthritis

vasculitis –> inflammation of blood vessels

nephritis –> inflammation of the kidneys