Pancreas Flashcards
1
Q
contrast the secretion of the acinas vs the ductule
A
2
Q
list 4 reasons how the pancreas doesn’t digest itself
A
- enzyme are made as inactive precursors called zymogen
- membrane-limited vacuoles prevents contact with cytoplasm until time for secretion
- activation occurs in the SI
- pancreas produces a trypsin inhibitor; safeguards against incidental activation of trypsin within the pancreas (inhibition of one prevents activation of many)
3
Q
describe the activation of pancreatic zymogens
A
- trypsinogen is released by the pancreas and is activated to trypsin after it reaches the lumen of the duodenum
- this separation prevents pancreatic damage since trypsin is a powerful protease and activates all other pancreatic zymogens
- enteropeptidase in the duodenum recognizes a specific amino acid sequence that is only found in trypsinogen
4
Q
describe how the activation of trypsin activates other digestive proteins
A
- protein digestion
- chymotrypsinogen to chymotrypsin
- proelastase to elastase
- procarboxypeptidase to carboxypeptidase
- lipid digestion
- procolipase to colipase
- prophospholipase A2 to phospholipase A2
5
Q
describe the secretion of the pancreatic ductal cells
A
- secretin stimulates bicarb secretion
- neutralizes acid from stomach
- composition changes with flow rate (see pic)
6
Q
describe the channels and transporters on the pancreatic ductal cells
A
7
Q
contrast the cephalic and intestinal phase of pancreatic secretions
A
8
Q
describe the control of pancreatic acinar secretion
A
9
Q
describe the pancreatic secretions during the cephalic phase
A
10
Q
describe the pancreatic secretions during the gastric phase
A
11
Q
describe the pancreatic secretions during the intestinal phase
A
12
Q
describe the function of secretion
A
