Allergy and Skin

Question 1

Define hypersensitivity

Answer 1

Immune responses that cause collateral damage to self

Question 2

What mediates type 1 hypersensitivity

Answer 2

IgE

Question 3

What mediates type 2 hypersensitivity

Answer 3

IgG

Question 4

What mediates type 3 hypersensitivity

Answer 4

Immune mediated complex

Question 5

What mediates type 4 hypersensitivity

Answer 5

T Cell mediated

Question 6

What is animal dander

Answer 6

Animal sheddings

Question 7

What 4 things do mast cells produce in a hypersensitivity reaction

Answer 7

Histamines
Leukotrienes
Cytokines
Prostoglandins

Question 8

What is urticaria

Answer 8

Itchy lesions that appear within the hour of contact with allergen

Question 9

Angioedema

Answer 9

Localized swelling of the subcutaneous tissue or mucous membrane

Question 10

Give 4 tests that can be done to test for an allergy

Answer 10

RAST test
Skin prick test
Challenge testing
Serum mast cell tryptase level

Question 11

When do you use challenge testing

Answer 11

If skin prick test is negative

Question 12

What treatment prevents the effects of mast cell activation

Answer 12

Anti-histamines

Question 13

What treatment is an anti-inflammatory

Answer 13

Cortiosteroids

Question 14

What treatment blocks mast cell activation

Answer 14

Sodium cromoglycate

Question 15

What is the dose for adults and what is the dose for children with adrenaline

Answer 15

300 micrograms

150 micrograms

Question 16

Describe type 4 hypersensitivities

Answer 16

Delayed hypersensitivity, T cell mediated and symptoms usually appear after 1/2 days

Question 17

What is the gold standard test for allergic contact dermatitis

Answer 17

Patch testing

Question 18

Is irritant contact dermatitis immune or non-immune mediated

Answer 18

Non-immune mediated