Ethanol and the CNS

Question 1

is a very soluble alcohol more potent than a less soluble one?

Answer 1

no, high solubility = low potency

Question 2

what is the function of the extracellular domain in cys-loop receptors?

Answer 2

binding site for:

1. neurotransmitter
2. competitive antagonists

Question 3

what is the function of the transmembrane domain in cys-loop receptors?

Answer 3

forms the central ion channel and is the binding site for allosteric regulators eg ethanol

Question 4

what is the function of the intracellular domain in cys-loop receptors?

Answer 4

interacts with the cytoskeleton, harbours sites for channel regulation

Question 5

drink drive limit in scotland?

Answer 5

10.9mM

Question 6

at what mM level would someone start expressing drunkenness?

Answer 6

after about 15mM alcohol

Question 7

what mM level would a coma be induced?

Answer 7

78mM plus