Neurotoxicology

Question 1

Two basic mechanisms of neurotoxicity?

Answer 1

1. .) Direct - agent itself is neurotoxic

2. ) Secondary damage - from hypoxia or hypoglycemia

Question 2

Chemicals that depress NS function?

Answer 2

Volatile solvents; interfere by blocking Ca receptors (resulting in an imbalance of inhibitory and excitatory pathways)

Question 3

Biology of axonal transport?

Answer 3

Long narrow cells can exceed 1 meter in length. Transport proteins and aid in intracellular communication

Question 4

Components of axonal transport?

Answer 4

Fast axonal transport - proteins
Intermediate transport - mitochondria, organelles
Slow transport - microfilaments, microtubules

Question 5

Mechanisms of neurotoxicity?

Answer 5

1. .) Neuronopathies - dmg to neuron
2. ) Axonopathies - dmg to axon
3. ) Myelinopathies - dmg to myelinating cells
4. ) Astrocytes - primary defense of CNS
5. ) Neurotransmission - associated w/ neurotoxicity