LYMPHOPROLIFERATIVE DISORDERS OBJECTIVES

Question 1

CANCER OF WBCS/BLOOD/BONE MARROW

Answer 1

Leukemia

Question 2

Increased total WBC count

Answer 2

Leukocytosis

Question 3

Increased neutrophil count

Answer 3

Neutrophilia

Question 4

Increased lymphocyte count

Answer 4

Lymphocytosis

Question 5

Decreased total leukocyte count

Answer 5

Leukopenia

Question 6

Decreased neutrophil count

Answer 6

Neutropenia

Question 7

Decreased lymphocyte count

Answer 7

Lymphoctyopenia

Question 8

All blood lineages decreased

Everything wiped out

Answer 8

Pancytopenia

Question 9

Describe Leukomoid reaction

What does it look like?

Answer 9

Leukemia like infection involving marked increase in neutrophilia…

Response to infection and is def not leukemia…
Most closely resembles Chronic Myelocytic Leukemia (CML)

Question 10

Differentiate acute lymphocytic leukemia (ALL), acute myelocytic
leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic
myelocytic leukemia (AML) in terms of which is most common in
adults, which is most common in children, sex/age of the afflicted,
laboratory diagnosis, and prognosis

Answer 10

Most common in Adults: CLL (>50 y/o)

Most common in children: ALL (3-7 y/o)

Question 11

Identify the bone marrow cell that is characteristic of Hodgkin’s
lymphoma, and identify the key characteristic(s) of each stage of
lymphoma progression

Answer 11

Hodgkins characterized by giant Reed-Sternberg cells

Stage 1: Cancer located in a single lymph node

Stage 2: 2 or more lymph node groups on one side of the diaphragm

Stage 3: Cancer has spread to both sides of the diaphragm, or involves the spleen

Stage 4: Cancer involves liver, bone marrow, lung and brain…
-highly metastasized

Question 12

Acute Lymphocyte Leukemia (ALL)

Answer 12

Most common in children ages 3-7 y/o
>20 % lymphoblastic in blood and marrow
-WBC’s very high or very low

-Tdt: lymphoblastic express Terminal deoxynucleotidyl transferase
>70% overall; 95% for children

Question 13

Acute Myeloid Leukemia (AML)

Answer 13

-Primarily adult median age 55 y/o
>20% blasts in blood or bone marrow
-WBC’s very high or low
Auer rods= crystallized granules in myeloblasts

-Death if untreated; 25% 5 yr survival overall

Question 14

Chronic Myeloid Leukemia (CML)

Answer 14

• Philadelphia chromosome
• Primarily Adult median age 50 y/o
• Elevated WBC 950-300K)
  - full spectrum of immature- mature neutrophils
• 60% 5 yr survival
  - Gleevec trials demonstrate >80% remission

Question 15

Chronic Lymphocytic Leukemia (CLL)

Answer 15

Most common Adult Leukemia
         -Adults: >50 y/o
Elevated WBC's (>20K)
        -lymphocytosis (75-98%)
        -may present as lymphoma
MEd survival ~10 years (stage 1 and 2)
<2 years (stages 3 and 4)