Anticancers - Antibodies & Inhibitors

Question 1

What is the mechanism of gemtuzumab, and is there anything unique about it?

Answer 1

EGFR-2, HER-2 antibodies, apoptosis, ADCC

Question 2

What is the mechanism of cetuximab, and is there anything unique about it?

Answer 2

antibody to EGFR-1, HER-1, apoptosis, ADCC

Question 3

What is the mechanism of trastuzumab, and is there anything unique about it?

Answer 3

antibody to EGFR-2, HER-2/neu, apoptosis, ADCC, disrupts ligand-independent heterodimers

Question 4

What is the mechanism of pantimumab, and is there anything unique about it?

Answer 4

antibody to EGFR-1, HER-1, apoptosis, aDCC

Question 5

What is the mechanism of bevacizumab, and is there anything unique about it?

Answer 5

antiboidy to VEGF, anti-angionegenesis

Hypertension, thromboembolic complicaications

Question 6

What is the mechanism of rituximab, and is there anything unique about it?

Answer 6

antibody to CD20, apoptosis, ADCC, CDC

Good for leukemias and lymphomas (CD20 is common on B cells)

Question 7

What is the mechanism of ofatumumab, and is there anything unique about it?

Answer 7

antibody to CD20, apoptosis, ADCC, CDC.

Good for leukemias and lymphomas (CD20 common on B cells)

Question 8

What is the mechanism of alemtuzumab, and is there anything unique about it?

Answer 8

antibody to CD52, apoptosis, ADCC, CDC

Hypotension

Question 9

What is the mechanism of Ibritumumab, and is there anything unique about it?

Answer 9

radiolabeled CD20 targeter, apoptosis, weak phagocytosis, irradiation.
Good for leukemias and lymphomas (CD20 common on B cells)

Question 10

What is the mechanism of tositumomab, and is there anything unique about it?

Answer 10

radiolabeled CD20 targeter, apoptosis, ADCC, CDC, irradiation.
Good for leukemias and lymphomas (CD20 common on B cells)

Question 11

What is the mechanism of pertuzumab, and is there anything unique about it?

Answer 11

EGFR-2, HER-2/neu, inbits formation of ligand-dependent heterodimers

Question 12

What is the mechanism of gefitinib, and is there anything unique about it?

Answer 12

EGFR tyrosine kinase inhibitor, EGFR-1,HER-1., Interfere with EGFR TK signaling

Question 13

What is the mechanism of erlotinib, and is there anything unique about it?

Answer 13

EGFR tyrosine kinase inhibitor, EGFR-1,HER-1., Interfere with EGFR TK signaling

Question 14

What is the mechanism of lapatinib, and is there anything unique about it?

Answer 14

EGFR tyrosine kinase inhibitor, EGFR-1,HER-1., EGFR-2, HER-2/neu. Inhibition of ligand-depedentand ligand-independent signaling.

Question 15

What is the mechanism of imatinib and dasatinib, and is there anything unique about it?

Answer 15

BCR-ABL tyrosine kinase inhibitors, BCR-ABL, KIT, PDGF, Src kinases, interefere with BCR-ABL TK signaling.
Edema

Question 16

What is the mechanism of nilotinib, and is there anything unique about it?

Answer 16

BCR-ABL TK inhibitor, BCR-ABL signaling interference

Question 17

What is the mechanism of sunitinib, sorafenib and pazopanib, and is there anything unique about it?

Answer 17

VEGF TK inhibitors

hypertension, QT prolongation

Question 18

What is the mechanism of bortezomib, and is there anything unique about it?

Answer 18

proteosome inhibitor, Targets 26S proteosome, NFkappaB causes transcription of pro-proliferative molecules and bortezomib binds it to prevent its action

Question 19

What is the mechanism of sirolimus, everolimus, and temsirolimus, and is there anything unique about it?

Answer 19

mTOR inhibitors, reduced ribosome synthesis and reduced protein translation

Question 20

What is the mechanism of interferon alpha 2, and is there anything unique about it?

Answer 20

antiviral and antineoplastic action. Promotes cell cycle arrest in G0 and induces apoptosis. Promotes CTLs and NK cells.