Acids and Bases Flashcards
1
Q
Advantages of generic name
A
- short and gives info about what the drug is used for
2
Q
Disadvantages of generic name
A
- little to no structural information
3
Q
Advantages of IUPAC
A
- used by researchers, particularly in chemical sciences to be structurally precise
4
Q
Disadvantages of IUPAC
A
- too long for easy use
5
Q
Advantages of proprietary name
A
- sounds good
6
Q
Disadvantages of proprietary name
A
- typically no useful information
7
Q
USAN
A
- attempted to systematize non-proprietary names of new compounds
- considers several criteria in evaluating potential names
8
Q
Who else must consent to a new name?
A
INN
9
Q
What can the hybridization of an atom tell you?
A
- number of atoms attached
- geometry around the atom
- recognize available p orbitals for delocalization
- amount of s and p character
10
Q
Delocalization
A
- spread election density charge
- greatly increases the stability of molecules
- profound effects on a functional groups reactivity and acid/base chemistry (drug properties)
11
Q
Aromaticity
A
- 4n + 2 pi electrons
- planar
- cyclic
- every atom in ring must participate in delocalizing the pi electrons
12
Q
Hydrocarbon properties
A
- unless very large, tend to be liquid/gases at room temp
- hydrophobic
- poor solubility in water
- expect a drug with a large hydrocarbon content to have poor bioavailability (doesn’t distribute well in biological fluids)
13
Q
KaS/pKaS
A
measure of how well a compound donates a proton (H0
14
Q
hydrophilicity
A
- charge contributes
- doesn’t have to be charged
- these properties have major impact on diffusion/crossing biological barriers/absorption
15
Q
With hydrophilicity you can predict
A
- duration of action
- bioavailability
- first pass extraction/metabolism
- CNS activity
