Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Therapeutics 2 - Fall 2017 > Serotonin Agonists > Flashcards

Serotonin Agonists Flashcards

1
Q

5-HT receptors:

1B does what?

A

mediate vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

5-HT receptors:

1D does what?

A

inhibit neurotransmitter release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

5-HT receptors:

1F does what?

A

inhibit release of nociceptive signaling molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is the structural difference between Ergotamine and Dihydroerotamine?

A

DHE does not have a double bond in a ring

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Ergots are selective for which subsets of serotonin receptors

A

2A; 1B; 1D; 1F

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Poor or Great Absorption of Ergots?

A

Poor

aka available as IM, nasal spray, SL tablet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Ergots are partial ________ receptor agonists

A

alpha1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

which ergot is less prone to cause severe peripheral vasoconstriction with frequent dosing

A

DHE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Do Ergots have short or long half lives

A

long

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

why do Ergots have a long half life

A

because they have active metabolites and and tight binding to tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what are the side effects of Ergots

A

GI (diarrhea, N/V)
causes uterine stimulants (aka contraindicated in pregnancy)
Gangrene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Triptans are selective for which subsets of serotonin receptors

A

1B, 1D, 1F

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

which triptan has the shortest half life

A

Sumtriptan and Rizatriptan (with 2 hr)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

which triptan has the longest half life

A

Frovatriptan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is the notable structural difference in Frovatriptan

A

it is TRICYCLIC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what drug is under study for selective 5-HT1F agonist

A

Lasmiditan

17
Q

why is selective 5-HT1F agonists beneficial

A

1F agonism can prevent Substance P, Neurokinin A, CGRP release (aka prevent inflammation)

18
Q

CGRP is a vaso_______

A

dilator

19
Q

CGRP potentiates ______

A

pain

20
Q

(Agonism or Antagonism) of CGRp receptor is effective for aborting migraine

A

Antagonism

21
Q

Rank the Drug Classes for Migraines with Most Risk for Vasospasm to Least Likely

A

MOST LIKELY: Ergot –> Triptans –> 5-HT1F

Therapeutics 2 - Fall 2017 (22 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions