Steroids

Question 1

aldosterone synthesis is stimulated by __________

Answer 1

angiotensin II and potassium

Question 2

hydrocortisone

Answer 2

short-acting glucocorticoid

replacement therapy for cortisol

Question 3

prednisolone

Answer 3

short-acting glucocorticoid

potent anti-inflammatory

Question 4

dexamethasone

Answer 4

long acting glucocorticoid

Used to diagnose cortisol disorders

Question 5

fludrocortisone

Answer 5

mineralocorticoid

Question 6

adrenal steroids are ______________ and ______________. Steroids are all made from ____________.

Answer 6

glucocorticoids and mineralocorticoids

cholesterol

Question 7

Which adrenal steroid is anti-inflammatory?

Answer 7

glucocorticoids

Question 8

Which adrenal steroid affects water and electrolyte balance?

Answer 8

mineralocorticoids

Question 9

which synthetic steroid has a high salt-retaining capacity?

Answer 9

fludrocortisone

Question 10

which synthetic steroid is best to replace mineralocorticoid deficiency?

Answer 10

fludrocortisone

Question 11

cortisol synthesis is stimulated by __________

Answer 11

ACTH

Question 12

ACTH release the ______________ is stimulated by CRH and inhibited by ________ (negative feedback).

Answer 12

anterior pituitary

Question 13

CRH (corticotropin releasing hormone) is released by the _____________ in response to stress or circadian rhythm.

Answer 13

hypothalamus

Question 14

List effects of glucocorticoids on protein, glucose, and lipid metabolism.

Answer 14

Increase hepatic gluconeogenesis via skeletal muscle protein breakdown
Increase hepatic glycogenolysis
Redistribution of body fat

Question 15

The effect of glucocorticoids on the immune system

Answer 15

suppress inflammatory immune response

Question 16

glucocorticoid toxicity is unusual as long as course is less than ________(Time frame)

Answer 16

2 weeks

Question 17

Abrupt withdrawal of exogenous glucocorticoids leads to:

Answer 17

acute adrenal insufficiency

Question 18

Potential complications of long-term high dose steroids

Answer 18

osteoporosis
hypertension
increased susceptibility to infection
Cushing’s type syndrome (striae, acne, fat redistribution)