Li-Fraumeni Syndrome (LFS) Flashcards by Michael Vrolijk | Brainscape

Q

What percentage of LFS is associated with a mutation of p53?

A

70%

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Q

What is the diagnostic criteria for LFS?

A

probing with a sarcoma diagnosed before 45 AND
first degree relative with any cancer under 45 years of age AND
a first or second degree relative with any cancer under 45 years of age or a sarcoma at any age

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Q

How is testing conducted for LFS or LFL?

A

next generation sequencing panels that include many cancer related genes

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