Hematology Uniques Flashcards

1
Q
  • decreased plts
  • decreased Hgb
  • increased LDH
A

primary thrombocytopenia

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2
Q
  • HgbS on hemoglobin electrophoresis

- sickled cells

A

Sickle cell anemia

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3
Q
  • eosinophilia, lymphocytosis

- low plts

A
  • immune thrombocytopenia purpura
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4
Q
  • elevated blasts
A

non-hodgkin’s lymphoma

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5
Q
  • neuro abnormalities/balance issues
  • normocytic or macrocytic anemia
  • elevated MMA
A

B12 deficiency anemia

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6
Q
  • elevated Hct

- elevated uric acid and vit B 12 level

A

polycythemia

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7
Q
  • positive direct Coomb’s test
A

Autoimmune helolytic anemia

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8
Q
  • pancytopenia w/ circulating blasts
  • auer rods
  • hyper cellular bone marrow
A

Acute Myeloid Leukemia

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9
Q
  • stool culture positive for e. coli, shiga toxin
A

hemolytic uremic syndrome

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10
Q
  • pancytopenia
  • macrocytic anemia
  • absent/few retics
  • empty/fatty bone marrow
A

Aplastic anemia

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11
Q
  • Reed-Sternberg cells
A

Hodgkin’s lymphoma

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12
Q
  • PT, PTT and bleeding times increased
A

Acquired disordered bleeding

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13
Q
  • “starry sky” pattern histologically due to benign macrophages interspersed among tumor cells
A

Burkitt’s lymphoma

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14
Q
  • ELISA positive for IgG PF4
A

HITT

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15
Q
  • only increased PTT
A

Hemophilia

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16
Q
  • scattered storage histiocytes with wrinkled, green-blue cytoplasm (sea-blue histiocytes)
A

CML

17
Q
  • Birbeck granules in cytoplasm
A

Langerhans cell histiocytosis

18
Q
  • decreased plts
  • anemia
  • schistocytes
  • decreased H+H
  • elevated LDH
  • very elevated indirect bilirubin
  • elevated BUN/Cr
  • decreased haptoglobin
  • positive ADAMTS-13
  • negative direct Coombs test
A

thrombotic thrombocytopenia purpura

19
Q
  • isolated lymphocytosis

- smudge cells on smear

A

chronic lymphocytic leukemia

20
Q
  • normal PT/INR
  • elevated PTT, bleeding time
  • abnormal vWF assays
A

vWF disease

21
Q
  • rouleaux formation on on smear
  • elevated beta-2 microglobulin
  • > 100 ratio on serum free monoclonal light chain assay
  • > 3 M spike on SPEP
  • Bence jones proteins on UPEP
A

Multiple myeloma

22
Q
  • elevated LDH

- presence of CD55/CD59 in flow cytometry

A
  • PNH
23
Q
  • microcytic, hypochromic anemia
  • decreased ferritin
  • increased iron binding capacity, transferrin
A

iron deficiency anemia

24
Q
  • terminal deoxynucleotidyl transferase
A

acute lymphoblastic leukemia

25
Q
  • leukocytosis w/ myeloid, left shift

- low LAP

A

Chronic myeloid leukemia

26
Q
  • normocytic/microcytic
  • low serum iron/transferrin
  • normal/increased ferritin
A

Anemia of Chronic disease

27
Q
  • agglutinated RBC on smear
  • elevated retics
  • serum cold agglutinin titer
A

Cold agglutinin disease

28
Q
  • ringed sideroblast
A

Erythroid myelodysplastic syndrome

29
Q
  • increased MCHC

- spherocytes

A

hereditary spherocytosis

30
Q
  • macrocytic anemia

- elevated homocysteine

A

Folic acid deficiency anemia

31
Q
  • heterophile antibody response IgM
A

EBV/Mono

32
Q
  • increased indirect bilirubin

- bite cells, heinz bodies in peripheral smear

A

G-6-P dehydrogenase deficiency