Oncology & Preventative Med

Question 1

1st line drugs to treat chemo induced nausea?

Answer 1

5 hydroxytryphtamine(5HT) inhibitors = Ondansetron, Ganisetron, Paolosetron & Dolasetron
*causes QT prolongation =/

Question 2

2st line drugs to treat chemo induced nausea?

Answer 2

Neurokinin-1(NK) = Aprepitant, Rolapitant, Netupitant

Question 3

3rd line drug to treat chemo induced nausea?

Answer 3

Glucocorticoids = dexamethasone

*can cause hypoglycemia and immunosuppresion but can increase appetitie

Question 4

breast cancers screening

Answer 4

50 - 75 yoa, mammography

Question 5

Tamoxifen

Answer 5

antagonists breast, agonst endometrium = increased risk of endo cancer + hot flashes + DVT risks

Question 6

Raloxifene

Answer 6

antagonizes breast and endo but can increase the risk of blood clots

Question 7

Anastrazole, Letrozole, Exemestane

Answer 7

Aromatase Inhibitors = increased risk of osteoporosis due to anti-estrogen

*no risk of DVT

Question 8

Colon Cancer screening

Answer 8

50q10 colonoscopy or occult blood testing 50q1

Question 9

Colon Cancer screening in person with family history of colon cancer

Answer 9

40q10 or 8/10 years before earliest family member dx

Question 10

Colon Cancer screening in person with HNPCC

dafuq is HNPCC?

Answer 10

HNPCC = 3 family members + 2 generations + 1 premature(<50)

colonoscopy at 25q1/2

Question 11

Colon Cancer screening in a person with FAP

Answer 11

sigmoidoscopy at 12q1/2

Question 12

Lung capacity needed for lobectomy

Answer 12

800mL

Question 13

Lung Cancer screening

Answer 13

55-75 with a 30 pk yr hx that hasnt quite within 15 yrs. annual chest CT

Question 14

Cervical Cancer Screening

Answer 14

21q3 till 29 then at 30q5 + HPV testing

Question 15

Cervical Cancer screening if Pap shows ASCUS

Answer 15

HPV testing if negative = repeat pap in 6-12m

Question 16

Cervical Cancer screening if Pap shows ASCUS + HPV positive

Answer 16

Colposcopy

Question 17

Prostate Cancer screening?

Answer 17

DRE. Only do PSA if pt requests it

Question 18

Flutamide

Answer 18

inhibits testo + DHT

*used to shrink prostate

Question 19

Leuprolide & Goserelin

Answer 19

GnRH agonist = will eventually lead to downregulation of FSH & LH

*used to shrink prostate

Question 20

Ketoconazole for prostate cancer

Answer 20

blocks androgens

Question 21

CA125 for ovarian cancer

Answer 21

used as a marker for progresssion of ovarian cancer not as a screening marker

Question 22

tx of testicular cancer?

Answer 22

radiation, chemo

Question 23

screening for Osteoporosis?

Answer 23

bone density at 65yoa

Question 24

screening for AAA

Answer 24

65-75 men who have EVER smoked 1x with U/S

Question 25

screening for hyperlipidemia

Answer 25

men >35 and women >45

Question 26

screening for HIV

Answer 26

15-65 at least 1x