prognosis

Question 1

DCIS

Answer 1

 Untreated: 1% → invasive cancer in the same quadrant w similar grade and expression of ER/HER2.
 Higher grade has a higher risk of progression.
 Death rate = better than the general pop’n as mammography may be a marker for socioeconomic status

Question 2

paget dis of nipple

Answer 2

depends on underlying carcinoma; not skin manifestations

Question 3

ER(+), HER2(-), Low Proliferation Invasive (infiltrating) Carcinoma

Answer 3

usu found early, cured y sx; low recurrence

Question 4

HER+ Invasive (infiltrating) Carcinoma

Answer 4

met early, when small –> viscera and brain

Question 5

ER(-), HER2(-) Invasive (infiltrating) Carcinoma

Answer 5

met early, when small –> viscera and brain
• Recurrence within 5 yrs of tx.
• Local recurrence = common, even w mastectomy.
• Prolonged survival after distant metastases is rare.

Question 6

medullary carcinoma

Answer 6

good bc good response to chemo

Question 7

inflammatory carcinoma

Answer 7

poor - 3yr survival 3-10%

Question 8

if the CA invades axillary LNs

Answer 8

10 yr survival
• No nodal involvement = 70-80%
• 1-3 (+) LNs = 35-40%
• 10 LNs = 10-15%

Question 9

if CA has lymphovasc invasion

Answer 9

bad prognosis, yes recurrence

Question 10

phyllodes tumor (cystosarcoma)

Answer 10

• low grade: can recur, not mets

- high grade: usu recurs

Question 11

angiosarcoma

Answer 11

poor bc high grade