Inflammation and Benign Breast Pathology

Question 1

When is nipple discharge worrisome?

Answer 1

Spontaneous and u/l

Question 2

What is the most common bacteria associated with acute mastitis?

Answer 2

Staph

Question 3

Sx’s = erythematous and painful breast with fever when newly breast feeding

Answer 3

Acute mastitis

Question 4

Sx’s = painful, erythematous subareolar mass that appears to be a bacterial abscess

Answer 4

Squamous Metaplasia of Lactiferous Ducts

Question 5

Squamous metaplasia of lactiferous ducts is highly associated with _____

Answer 5

Smokers

Question 6

Morph: keratinizing squamous metaplasia of the nipple ducts

Answer 6

Squamous metaplasia of lactiferous ducts

Question 7

Sx’s = palpable periareolar mass associated with thick, white nipple secretions and skin retraction

Answer 7

Duct ectasia

Question 8

Morph: ectatic ductules filled with lipid-laden macrophages

Answer 8

Duct ectasia

Question 9

Sx’s = painless, palpable mass with skin thickening/retraction and mammogramic densities/calcifications after trauma or surgery

Answer 9

Fat necrosis

Question 10

Morph: acute lesions that may be hemorrhagic and have central areas of liquefactive necrosis

Answer 10

Fat necrosis

Question 11

Lymphocytic mastopathy is more common in women with _____ or _____

Answer 11

DM1

Autoimmune thyroid disease

Question 12

Sx’s = hard palpable masses or mammogramic densities that are difficult to obtain a biopsy from

Answer 12

Lymphocytic mastopathy

Question 13

Morph: atrophic ducts and lobules with thickened basement membranes

Answer 13

Lymphocytic mastopathy

Question 14

Mastitis that only occurs in parous women and may be a fungal infection if associated with immunosuppression or foreign objects

Answer 14

Granulomatous mastitis

Question 15

Which type of benign epithelial lesion is not associated with an increased risk of breast cancer

Answer 15

Nonproliferative changes (fibrocystic)

Question 16

Which type of benign epithelial lesions of the breast are associated with an increased risk of breast cancer?

Answer 16

Proliferative disease…
Without atypia = small increase
With atypia = moderate increase

Question 17

Morph: increased collagenous CT with epithelial hyperplasia of the duct lining with tapering micropapillae and E and androgen imbalance in a male

Answer 17

Gynecomastia

Question 18

Gynecomastia is associated with _____ and _____

Answer 18

Cirrhosis

Klinefelter syndrome

Question 19

Atypical lobular hyperplasia shows loss of _____ (AKA “Pagetoid”)

Answer 19

E-cadherin

Question 20

Morph: monomorphic proliferation of regularly spaced cells, sometimes with cribriform spaces

Answer 20

Atypical ductal hyperplasia

Question 21

Morph: cells identical to those of lobular CIS but fill < 50% of acini within a lobule

Answer 21

Atypical lobular hyperplasia

Question 22

Proliferative breast disease with atypia is associated with which chrom anomalies?

Answer 22

Loss of chrom 16q

Gain of chrom 17p