Substance misuse

Question 1

The use of amphetamine can cause what?

Answer 1

Psychosis

Question 2

Chronic intravenous injecting can cause what?

Answer 2

Poor vascular return

Question 3

What is the effective dose range for methadone?

Answer 3

60-120mg

Question 4

For methadone doses of 100mg and greater, what should be performed and why?

Answer 4

ECG because of the link with prolonged QTc and Torsades des Pointes syndrome.

Question 5

Is detoxification or maintenance usually preferred for younger people?

Answer 5

Detoxification

Question 6

Detoxification with methadone or buprenorphine has less prolonged withdrawal effects?

Answer 6

Buprenorphine

Question 7

What is Methadone?

Answer 7

Synthetic opioid receptor agonist

Question 8

What is Buprenorphine?

Answer 8

Both partial opioid agonist and opioid antagonist

Question 9

What is the elimination half life of Methadone?

Answer 9

20-37 hours

Question 10

What examples of drugs speed up the elimination of methadone?

Answer 10

Rifampicin, phenytoin, phenobarbital

Question 11

What examples of drugs slow down the elimination of methadone?

Answer 11

Fluvoxamine

Fluoxetine

Question 12

What is the maximum daily dose of buprenorphine?

Answer 12

32mg

Question 13

Which drugs can be supplied in instalments?

Answer 13

Schedule 2 CDs
Buprenorphine
Buprenorphine/Naloxone (Suboxone)
Diazepam

Question 14

What are the symptoms of opioid withdrawal?

Answer 14

Yawning, dilated pupils, clammy skin, diarrhoea, tremor, irritability, anxiety, increased BP

Question 15

What are the symptoms of methadone overdose?

Answer 15

Small pinpoint pupils, nausea, constipation, stomach or intestinal spasm, vomiting, difficulty breathing