APAS

Question 1

Characteristic of APAS

Answer 1

autoantibody-mediated ACQUIRED thrombophilia, recurrent arterial or venous thrombosis and/or pregnancy morbidity

Question 2

Mottled reticular vascular pattern, lace-like, purplish discoloration of the skin

Answer 2

Livedo reticularis

Question 3

Very small vegetations, platelet-rich microthrombi surrounded by growing fibroblasts and macrophages

Answer 3

Libman-Sacks endocarditis

Question 4

Lab findings associated with APAS

Answer 4

Coombs-positive hemolytic anemia

and thrombocytopenia

Question 5

Diagnosis of APAS

Answer 5

> or equal to 1 clinical +
or equal to 1 laboratory
even in the presence of other causes of thrombophilia

Question 6

Clinical Criteria of APAS

Answer 6

Vascular Thrombosis

Pregnancy morbidity

Question 7

Lab criteria for APAS

Answer 7

intermediate or high titers on 2 occasions 12 weeks apart of
LA
Anticardiolipin
Anti-B2GPI antibodies

Question 8

Treament for APAS

Answer 8

LIFETIME anticoagulation after the first thrombotic event
Warfarin to achieve INr 2.5-3.5

if pregnant
Heparin with aspirin
IVIg 400mkd x 5 days

GCs no role