PSC

Question 1

Primary sclerosing cholangitis is associated with which other medical condition?

Answer 1

inflammatory bowel disease (ulcerative colitis)

Question 2

Describe each stage of primary sclerosing cholangitis.

Answer 2

I-portal: portal edema, inflammation, ductal proliferation; II-periportal: periportal fibrosis +/- inflammation beyond limiting plate; III-septal: septal fibrosis, bridging necrosis or both; IV-cirrhotic: biliary cirrhosis

Question 3

Where is the most common location for development of a dominant biliary stricture?

Answer 3

at or near hepatic duct bifurcation

Question 4

What is the incidence of cholangiocarcinoma in patients with PSC?

Answer 4

10-15%

Question 5

How is small duct PSC diagnosed?

Answer 5

liver biopsy

Question 6

What serological abnormalizities can be found in patients with PSC?

Answer 6

antinuclear, antismooth muscle, anticardiolipin antibioties

Question 7

What is the surgical procedure for patients with dominant strictures associated with PSC?

Answer 7

complete resection of extrahepatic biliary tree and reconstruction using Roux-en-Y hepaticojejunostomy +/- stent

Question 8

What percentage of OLTs in the US are done for PSC?

Answer 8

5%

Question 9

What percentage of patients recur after liver transplantation?

Answer 9

15-20%