Olfaction and the limbic system Flashcards

1
Q

How many different odours are there?

A

2000-4000

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2
Q

What are the different types of cells of olfactory epithelium?

A

Bipolar olfactory neurons

Sustentacular cells

Basal cells

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3
Q

Label the following diagram:

A
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4
Q

What are the key landmarks of the olfactory system?

A

Olfactory bulb (mitral cells)

Olfactory tract

Olfactory stria (medial and lateral)

Piriform cortex and orbitofrontal cortex

Connections to brainstem promote autonomic responses

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5
Q

What is a clinical deficit of the olfactory system?

A

Anosmia

Prodromal auras- temporal lobe epilepsy pre-seizure.

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6
Q

Label the following diagram:

A
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7
Q

What is the limbic system responsible for?

A

Processes aimed at survival of the individual.

Maintenance of homeostasis via activation of visceral effector mechanisms, modulation of pituitary hormone release and initiation of feeding and drinking.

Agonistic (defence and attack) behaviour.

Sexual and reproductive behaviour.

Memory.

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8
Q

What is the limbic system?

A

Rim or limbus of cortex adjacent to corpus callosum and diencephalon.

Structurally and functionally interrelated areas considered as a single functional complex.

System responsible for processes aimed at survival of the individual.

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9
Q

Complete the following flow chart of the Papez circuit:

A
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10
Q

What is the main output pathway of the hippocampus?

A

Fornix.

Travels out of the inferior horn of the lateral ventrical (in ventrical floor), up and forward and down to the hypothalamus- specifically to mammillary bodies.

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11
Q

What connects the hypothalamus to the anterior nucleus of the thalamus?

A

MTT- mammillothalamic tract

Emotional expression

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12
Q

In the Papez circuit, what does the anterior nucleus of the thalamus project to?

A

Cingulate cortex- just above corpus callosum.

Emotional experience.

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13
Q

In the Papez circuit, what does the cingulate cortex project to?

A

Hippocampus via cingulum bundles.

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14
Q

What are the three levels of emotional interaction in the Papez circuit?

A

Emotional colouring- neocortex

Emotional experience- cingulate cortex

Emotional expression- hypothalamus

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15
Q

What are the main connections of the hippocampus?

A

Afferent- perforant pathway

Efferent- fimbria/ fornix

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16
Q

What are the functions of the hippocampus?

A

Memory (short term) and learning.

17
Q

What conditions is the hippocampus clinically significant to?

A

Alzheimer’s disease

Epilepsy

18
Q

Label the following diagram:

A
19
Q

Describe the anatomical progression of Alzheimer’s disease.

A

Early:

  • hippocampus and entorhinal cortex
  • short-term memory problems

Moderate:

  • parietal lobe
  • dressing apraxia

Late:

  • frontal lobe
  • loss of executive skills
20
Q

What are the main connections of the amygdala?

A

Afferent- olfactory cortex, septum, temporal neocortex, hippocampus, brainstem

Efferent- stria terminalis

21
Q

What are the functions of the amygdala?

A

Fear and anxiety

Fight or flight

22
Q

Give an example of a condition in which the amygdala is clinically involved.

A

Bilateral damage- Kluver-Bucy syndrome.

23
Q

What is Kluver-Bucy syndrome?

A

Syndrome originally described in monkeys with bilateral temporal lobectomy.

Hyperorality

Loss of fear

Visual agnosia

Hypersexuality

24
Q

What structures have been experimentally shown to be associated with aggression?

A

Hypothalamus

Brainstem (periaqueductal grey)

Amygdala

5-HT in raphe nuclei

25
Q

What are the main connections of the septum?

A

Afferent- amygdala, olfactory tract, hippocampus, brainstem

Efferent- stria medularis thalami, hippocampus, hypothalamus

26
Q

What are the functions of the septum?

A

Reinforcement and reward

27
Q

Label the following diagram:

A