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heme/lymph > 14 morph > Flashcards

14 morph Flashcards

1
Q

normocytic normochromic

A

anemia of acute blood loss

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2
Q

RBCs small, hyperchromic, lacking central pallor

A

hereditary spherocytosis (HS)

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3
Q

Howell-jolly bodies

A

in asplenia?

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4
Q

Heinz bodies

A

G6PD

=dark inclusions visible with crystal violet

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5
Q

bite cells

A

G6PD

=as Mfs remove heinz bodies

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6
Q

Peripheral blood: irreversibly sickled cells, reticulocytosis and target cells d/t RBC dehydration

A

Sicklce cell anemia

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7
Q

chronically dehydrated, dense, rigid RBCs

A

SCA end stage

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8
Q

microcytic, hypochromic RBCs

A

B-thalassemia

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9
Q

RBCs relesed from BM have inclusions –> extravasc hemolysis

A

B-thalassemia

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10
Q

massive erythroid hyperplasia

A

B-thalassemia

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11
Q
  • Anisocytosis (variable RBC size).
  • Poikilocytosis (variable shape).
  • microcytosis
  • Hypochromia.
  • Target cells.
  • Basophilic stippling.
  • Fragmented RBCs
A

B-thalassemia

-(all except snisocytosis and pokilocytosis = minor)

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12
Q

Hb Barts

A

Infants w a-thalassemia: unpaired γ-globin chains form tetramers: 4 deletions

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13
Q

HbH

A

Adults w a-thalassemia: unpaired β-globin chains form tetramers : 3 deletions

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14
Q

IgG (sometimes IgA) Abs to RBCs

A

Warm Ab Type of immunohemolytic anemia

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15
Q

RBCs = spherocytes

A
  • hereditary spherocytosis (HS)

- Warm Ab Type of immunohemolytic anemia

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16
Q

IgM to RBC at low temps

A

Cold Agglutinin type of immunohemolytic anemia

17
Q

IgG autoAbs bind to the P group Ag on the RBC surface in cool, peripheral regions of the body.

A

Cold Hemolysin type of Immunohemolytic Anemias

18
Q

Schistocytes

A

Microangiopathic Hemolytic Anemia d/t trauma

19
Q

burr cells

A

Microangiopathic Hemolytic Anemia d/t trauma

20
Q

helmet cells

A

Microangiopathic Hemolytic Anemia d/t trauma

21
Q

triangle cells

A

Microangiopathic Hemolytic Anemia d/t trauma

22
Q

abn lg erythroid precursors

A

megaloblastic anemia

=megaloblasts

23
Q

PB: Macro-ovalocytes: large, oval RBCs*

A

megaloblastic anemia

24
Q

PB: Hyperchromic d/t ample Hb (lack fentral pallor)

A

megaloblastic anemia

25
Q

PB: MCHC is not elevated

Decreased reticulocyte count

A

megaloblastic anemia

26
Q

PB: Aniscocytsosis and poikilocytosis (variable size and shape) of the RBCs.

A

megaloblastic anemia

27
Q

PB: Hypersegmented neutrophils ( > 5 lobes)

A

megaloblastic anemia

28
Q
  • Hypercellular marrow
  • Promegaloblasts (most primitive cells) large with very basophilic cytoplasm, prominent nucleoli, and fine nuclear chromatin pattern.
  • nuclear to cytoplasmic asynchrony.
  • Giant metamyelocytes and band forms.
A

BM in megaloblastic anemia

29
Q

giant myelocytes and metamyelocytes

A

pernicious anemia

30
Q

Microcytic, hypochromic anemia in blood smears, but is normocytic, normochromic in the beginning.

A

iron deficient anemia

31
Q

Central pallor is enlarged in RBCs and Hb may only be seen in a narrow peripheral rim

A

iron deficient anemia

32
Q

Poikilocytosis (pencil cells)

A

iron deficient anemia

33
Q
  • Hypocellular bone marrow
  • -‘Dry tap’ on marrow aspiration, bone marrow bx necessary for dx
  • Granulocytopenia
  • Thrombocytopenia
  • Systemic hemosiderosis
A

aplastic anemia

34
Q

nml sized spleen
increased # megakaryocytes
megathrombocytes

A

Chronic Immune Thrombocytopenic Purpura (ITP)

35
Q

B/l renal cortical necrosis

A

DIC

36
Q

ARDS if pulmonary vasculature is involved.

A

DIC

37
Q

CNS: microinfacrst, which can be complicated by hem

A

DIC

38
Q

Adrenals: waterhouse-friderichsen synd causes fibrin thrombi in meningococcemia

A

DIC

39
Q

Giant hemangiomas: kasabach-merritt syndrome (thrombi form in neoplasms).

A

DIC

heme/lymph (18 decks)

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