Lecture 24

Question 1

Intrinsic polarity

Answer 1

the signaling comes from within the cell using a GTPase protein

Question 2

how can Asymmetric cell division can be extrinsically divide

Answer 2

External signals that come from other cells or from extracellular matrix and move polarity complexes to one side = polarity

Question 3

par proteins

Answer 3

polarity complexes establishing polarity in epithelial cells,

Question 4

Apical par complex

Answer 4

complex of proteins that will trigger the assembly of cadherins and tight junctions

Question 5

Crumbs complex

Answer 5

ends up being the apical domain of cell, activated by par complex

Question 6

Scribble complex

Answer 6

becomes the basolateral

Question 7

Apoptosis

Answer 7

important program/process during normal development

Question 8

three classes of proteins involved in apoptosis

Answer 8

killer, destruction, engulfment

Question 9

killer proteins

Answer 9

initiates apoptosis pathway

Question 10

destruction proteins

Answer 10

blebs = apoptotic bodies

Question 11

engulfment proteins

Answer 11

trigger phagocytosis

Question 12

necrosis

Answer 12

when a cell breaks open, lyses, and releases its contents into the environment

Question 13

two general classes of proteins

Answer 13

pro-survival, pro-apoptotic

Question 14

pro-survival proteins

Answer 14

Bcl-2 (anchored in outer mitochondrial membrane)

Question 15

pro-apoptotic proteins

Answer 15

Bax, Bak (anchored in outer mitochondrial membrane)

Question 16

what inactivates apoptosis?

Answer 16

trophic factor = phosphorylates Bad = can’t change Bcl-2

Question 17

Cell murder

Answer 17

extrinsic apoptosis pathway

Question 18

What do the “killer cells” have on their cell surface that kills their target cell?

Answer 18

signaling molecules on its surface that it will use to bind to signal receptors of target cell