Coagulation

Question 1

Primary hemostasis

Answer 1

platelet adhesion (platelets stick to damaged endothelium- exposed subendothelial collagen with vwf, platelets bind to vwf) 
platelet aggregation- clump together after being activated and getting sticky

Question 2

secondary hemostasis

Answer 2

extrinsic pathway- VII (tissue factor, normally sequestered, expressed on fibroblasts, activated endothelium and platelets)

intrinsic- hmwk, pk, XII, XI, IX, VIII

both lead to X, V, II, I (common pw)

XIII- fibrin stabilization

Question 3

screening for primary hemostasis

Answer 3

platelet count- if low cannot form platelet aggregation

bleeding time

vwd can lead to prolonged bleeding time

Question 4

fibrinolysis screening

Answer 4

d-dimer/fdp

test for DIC

Question 5

pt

Answer 5

add tissue factor and phospholipid 2- activates extrinsic system

tests VII, and common pw proteins- X, V, II, I

high in liver disease, coumadin/ warfarin therapy

Question 6

ptt

Answer 6

deficiency in intrinsic and common pathway

hemophilia A (VIII) and hemophilia B (IX)