STDs

Question 1

Genital Herpes

Answer 1

Herpes simplex Type II virus - targets neuron cells (neurotropic microbe)

One of the most common infections
Recurrent, systemic viral infection
Can become latent
Spread via contact with lesions or secretions

Question 2

Genital Warts

Answer 2

HPV (Human Papilloma virus)
Infection (6 & 11 strains)
Skin to skin contact
Multiple benign lesions
Genital and anorectal region (can appear on other regions)
~2-8 months incubation
Most asymptomatic & transient

Tx: no cure
wart removal (topical, cryotherapy, Sx)
Monitor for CA (type 16 &18 strains)

Question 3

Syphilis (bacterial)

Answer 3

Treponema pallidum infection
Spread via contact with lesions (portal of entry is needed to infect & defenses are impaired)
Also through placenta (after 16 weeks)

Complications:
blindness, paralysis, cardiac problems, death?
well defined stages

Question 4

HIV

Answer 4

Human Immunodeficiency Virus

Question 5

Genital Herpes - Mnfts

Answer 5

Local: burning, painful vesicles at site
Systemic: fever, myalgia

Can be subclinical (no appearance of related signs of infection > worsens detection)

Anatomical differences:
Females: higher surface area, so more prone to contract; also less visible.
Males: penis and scrotum; lesions are visible and external

Question 6

Syphilis (bacterial): stages

Answer 6

1º Stage: 
multiple lesions = chancre at exposure site
can escape dectection
~4 weeks post exposure
heals in 3-4 weeks
regional lymphadenopathy

2nd Stage: (up to 6 months) 
if untreated 6-8 weeks post infection
patches on mucous membranes (tongue)
maculopapular rash on palms and soles
flat papules
generalized lymphadenopathy
fever, malaise
latent period (30 years) >>> NO CLINICAL SIGNS but pt is seropositive

3rd Stage:

Question 7

Syphilis (bacterial): stages

Answer 7

1º Stage: 
multiple lesions = chancre at exposure site
can escape dectection
~4 weeks post exposure
heals in 3-4 weeks
regional lymphadenopathy

2nd Stage: (up to 6 months) 
if untreated 6-8 weeks post infection
patches on mucous membranes (tongue)
maculopapular rash on palms and soles
flat papules
generalized lymphadenopathy
fever, malaise
latent period (30 years) >>> NO CLINICAL SIGNS but pt is seropositive

3rd Stage: 1-35 years after pulmonary infection
irreversible systemic damage (skeleton, CVS, NS)

Question 8

Syphilis: Tx

Answer 8

Antibiotics - long-acting penicillin

“generation period”: time required in a colony to double in size > Treponema = 30hr

Question 9

Syphilis: Tx

Answer 9

Antibiotics - long-acting penicillin

“generation period”: time required in a colony to double in size > Treponema = 30hr vs E.coli = 20 min