HIV and Hepatitis C

Question 1

What two drugs inhibit reverse transcriptase activity?

Answer 1

Non-nucleoside RT inhibitors (NNRTIs) and nucleoside analogue RT inhibitors (NRTIs)

Question 2

Examples of NNRTIs

Answer 2

–VIR–

E.G EfaVIRenz, NeVIRapinem DelaVIRdine and EtraVIRdine

Question 3

Example of NRTIs

Answer 3

Azidothymidine AZT

Question 4

Two examples of protease inhibitors for HIV treatment

Answer 4

Saquinavir and Nelfinavir

Question 5

What is combination treatment for HIV known as

Answer 5

HAART

Question 6

What three parts of the HCV promoter is targeted

Answer 6

NS3, NS5A and NS5B

Question 7

What is NS3 responsible for

Answer 7

Replication of the virus, protease and helicase (can unwind genomes).

Question 8

What is NS5B responsible for

Answer 8

RNA-dependent RNA polymerase, makes an RNA compy of the RNA genome

Question 9

what is NS5A responsible for

Answer 9

key target for antiviral therapy

Question 10

What two 1st generation drugs inhibit NS3

Answer 10

Telaprevir and Boceprevir, have high resistance

Question 11

What 2nd generation drug inhibits NS3

Answer 11

Simeprevir

Question 12

Drugs that inhibit NS5B

Answer 12

Sofosbuvir

Question 13

Two drugs inhibiting NS5A

Answer 13

Daclatasivir and Ledipasvir