Packaging, Communition, Mixing & Drying Flashcards
Why is packaging needed?
To guarantee stability of the drug and for the delivery of medicines in a range of dosage forms
What are the functions of a pack?
Contain, protect, present, identify and convenience
What are the components of a pack?
1° pack contains product & protects it
2° pack offers additional protection, facilitates transport, gives clear and concise information
3° pack is for bulk handling and shipping
What properties should closures have?
- Hermetic seal
- microbiological seal
- inert
- compatible with product & protect against hazards
What is the purpose of a tamper evident seal?
Ensure patient safety
How can the efficacy of a closure be tested?
- Moisture detection
- Moisture loss
- Seal efficiency
How is glass produced?
By heating silica, calcium carbonate, and sodium carbonate
What does alumina do to glass?
Increases hardness, durability and clarity
What do selenium / cobalt do to glass?
Improves clarity
What do boron compounds do to glass?
Low thermal expansion and high heat shock resistance
What colour of glass is a result of Fe 3+ oxides?
Amber (useful for preventing photo degradation)
What colour of glass is a result of Fe 2+ oxides?
Green (used for packaging beverages)
What are the advantages of using plastic for packaging?
- Quality of material
- Fabrication
- Easy to design
- Good physical and chemical properties
- Cheap
What are the disadvantages of using plastic for packaging?
- Sensitive to temp variation
- Chemical stability
- Influenced by temperature and humidity
- Gas permeation
What are the advantages of using metal for packaging?
- strong
- withstand pressures of MDIs
- shatterproof
- maleable
- you can tailor hardness
