Bioinformatics 1 Flashcards
some examples of bio-informatic data/analysis
DNA sequencing, gene identification, RNA structure prediction, DNA microsatellite analysis in forensics
some general areas of use
forensics, livestock breeding, medicine, microbes for energy and the environment
what is the central dogma
DNA transcribes to RNA translated to PROTEIN
define homology
inheritance comes from a common ancestor
if genes are homologous…
their functions are likely to be the same
to identify homologues what do you search by
accession number
what is sickle cell anaemia and what is it an example of
inherited blood disorder, variation in sequence that correlates with phenotype
what is archaea
3rd domain of life - treated differently to other prokaryotes
about how many complete genomes do we have, and from what
about 6000, from bacteria, archaea, eukaryotes
what has a very big genome size
T2 phage virus
What is our genome size
3.2 billion bp
what is Deep seq
nest generation sequencing - small device - long sequences of DNA
why do you need to give genomes unique ID’s when sequencing them
so you can go back later, predict functions and incorporate experimental data
what is a network analysis
shows proteins and all their interactions - looks like a spiders web
what do the different coloured balls in the network analysis signify
the phenotypic effect of removing that protein - lethal/non lethal/slow growth/ unknown
