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2S - PCT > 7 Intro to CNS Drugs: Toxins used to characterize ion channels > Flashcards

7 Intro to CNS Drugs: Toxins used to characterize ion channels Flashcards

1
Q

Voltage Gated: Sodium Channels

TETRODOTOXIN (TTX)

  • Mode of Toxin Action: _______________
  • Source: ________________
A
  • Mode of Toxin Action: Blocks channel from outside
  • Source: Puffer Fish
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2
Q

Volatage Gated: Sodium Channels

BATRACHOTOXIN (BTX)
- Mode of Toxin Action: _______________
- Source: ________________

A
  • Mode of Toxin Action: Slows inactivation, shifts activation
  • Source: Colombian Frog
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3
Q

Voltage Gated: Potassium Channels

APAMIN
- Mode of Toxin Action: _______________
- Source: ________________

A
  • Mode of Toxin Action: Blocks “small Ca-activated” K channel
  • Source: Pacific cone snail
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4
Q

Voltage Gated: Potassium Channels

CHARYBDOTOXIN
- Mode of Toxin Action: _______________
- Source: ________________

A
  • Mode of Toxin Action: Blocks “big Ca-activated K “channel
  • Source: Funnel web spider
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5
Q

Voltage Gated: Calcium Channels

OMEGA CONOTOXIN
- Mode of Toxin Action: _______________
- Source: ________________

A
  • Mode of Toxin Action: Blocks N-type
    channel
  • Source: Pacific cone snail
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6
Q

Determine what channel of Voltage Gated:

Charybdotoxin

Blocks “big Ca-activated K “channel
From: Funnel web spider

A

Potassium channels

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6
Q

What are the 3 Channels in Voltage Gated?

A
  • Sodium Channels
  • Potassium Channels
  • Calcium Channels
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6
Q

Determine what channel of Voltage Gated:

Omega Conotoxin

Blocks N-type channel
From: Pacific cone snail

A

Calcium Channels

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6
Q

Voltage Gated: Calcium Channels

Agatoxin
- Mode of Toxin Action: _______________
- Source: ________________

A
  • Mode of Toxin Action: Blocks P-type
    channel
  • Source: Funnel web spider
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7
Q

Determine what channel of Voltage Gated:

Tetrodotoxin (TTX)

Blocks channel from outside
From: Puffer Fish

A

Sodium Channels

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7
Q

Determine what channel of Voltage Gated:

Batrachotoxin (BTX)

Slows inactivation, shifts activation
From: Colombian Frog

A

Sodium Channels

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8
Q

4 Receptors in Ligand Gated

A
  • Nicotine ACh receptor
  • GABAa Receptor
  • Glycine Receptor
  • AMPA Receptors
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8
Q

Determine what channel of Voltage Gated:

Apamin

Blocks “small Ca-activated” K channel
From: Pacific cone snail

A

Potassium Channels

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8
Q

LIGAND GATED

Nicotine ACh receptor Affected by Cx - bungarotoxin

  • Mode of Toxin Action: ________
  • Source: ________
A
  • Mode of Toxin Action: Irreversible antagonist
  • Source: Marine snake
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9
Q

Determine what channel of Voltage Gated:

Agatoxin

Blocks P-type channel
From: Funnel web spider

A

Calcium Channels

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10
Q

Ligand Gated:

AMPA receptor is affected by:

A

Philanthotoxin

10
Q

Ligand Gated:

Nicotine ACh receptor is affected by:

A

Cx - Bungarotoxin

10
Q

Ligand Gated:

Glycine receptor is affected by:

A

Strychnine

10
Q

Ligand Gated:

GABAa receptor is affected by:

A

Picrotoxin

11
Q

LIGAND GATED

Glycine receptor Affected by Strychnine

  • Mode of Toxin Action: ________
  • Source: ________
A
  • Mode of Toxin Action: Competitive
    antagonist
  • Source: Indian Plant
12
Q

LIGAND GATED

GABAa RECEPTOR Affected by Picrotoxin

  • Mode of Toxin Action: ________
  • Source: ________
A
  • Mode of Toxin Action: Blocks channel
  • Source: South Pacific Plant
13
Q

LIGAND GATED

AMPA Receptors Affected by Philanthotoxin

  • Mode of Toxin Action: ________
  • Source: ________
A
  • Mode of Toxin Action: Blocks channel
  • Source: Wasp
14
Q

Determine what Ligand Gated
Mode of Toxin Action: Competitive antagonist
Source: Indian Plant

  • Nicotinic ACh receptor Affected by: Cx - Bungarotoxin
  • GABAa RECEPTOR Affected by: Picrotoxin
  • Glycine receptor Affected by: Strychnine
  • AMPA Receptors Affected by: Philanthotoxin
A

Glycine receptor Affected by: Strychnine

14
Q

Determine what Ligand Gated
Mode of Toxin Action: Blocks channel
Source: Wasp

  • Nicotinic ACh receptor Affected by: Cx - Bungarotoxin
  • GABAa RECEPTOR Affected by: Picrotoxin
  • Glycine receptor Affected by: Strychnine
  • AMPA Receptors Affected by: Philanthotoxin
A

AMPA Receptors Affected by: Philanthotoxin

15
Determine what Ligand Gated Mode of Toxin Action: Blocks channel Source: South Pacific Plant - Nicotinic ACh receptor Affected by: Cx - Bungarotoxin - GABAa RECEPTOR Affected by: Picrotoxin - Glycine receptor Affected by: Strychnine - AMPA Receptors Affected by: Philanthotoxin
GABAa RECEPTOR Affected by: Picrotoxin
16
Determine what Ligand Gated Mode of Toxin Action: Irreversible antagonist Source: Marine snake - Nicotinic ACh receptor Affected by: Cx - Bungarotoxin - GABAa RECEPTOR Affected by: Picrotoxin - Glycine receptor Affected by: Strychnine - AMPA Receptors Affected by: Philanthotoxin
Nicotinic ACh receptor Affected by: Cx - Bungarotoxin
16
Determine what Voltage Gated Mode of Toxin Action: Blocks channel from outside Source: Puffer fish - Sodium channels: Tetrodotoxin (TTX) - Sodium channels: Batrachotoxin (BTX) - Potassium channels: Apamin - Potassoum channels: Charybdotoxin - Calcium channels: Omega conotoxin - Calcium channels: Agatoxin
Sodium channels: Tetrodotoxin (TTX)
17
Determine what Voltage Gated Mode of Toxin Action: Slows inactivation, shifts activation Source: Colombian Frog - Sodium channels: Tetrodotoxin (TTX) - Sodium channels: Batrachotoxin (BTX) - Potassium channels: Apamin - Potassoum channels: Charybdotoxin - Calcium channels: Omega conotoxin - Calcium channels: Agatoxin
Sodium channels: Batrachotoxin (BTX)
17
Determine what Voltage Gated Mode of Toxin Action: Blocks “small Ca-activated” K channel Source: Pacific cone snail - Sodium channels: Tetrodotoxin (TTX) - Sodium channels: Batrachotoxin (BTX) - Potassium channels: Apamin - Potassoum channels: Charybdotoxin - Calcium channels: Omega conotoxin - Calcium channels: Agatoxin
Potassium channels: Apamin
18
Determine what Voltage Gated Mode of Toxin Action: Blocks “big Ca-activated K “channel Source: Funnel web spider - Sodium channels: Tetrodotoxin (TTX) - Sodium channels: Batrachotoxin (BTX) - Potassium channels: Apamin - Potassoum channels: Charybdotoxin - Calcium channels: Omega conotoxin - Calcium channels: Agatoxin
Potassoum channels: Charybdotoxin
18
Determine what Voltage Gated Mode of Toxin Action: Blocks N-type channel Source: Pacific cone snail - Sodium channels: Tetrodotoxin (TTX) - Sodium channels: Batrachotoxin (BTX) - Potassium channels: Apamin - Potassoum channels: Charybdotoxin - Calcium channels: Omega conotoxin - Calcium channels: Agatoxin
Calcium channels: Omega conotoxin
18
Determine what type of channels: - They will close or open depending on the charge inside and outside of the neurons - Charge affected - Affected by membrane potential, not directly affected by drugs - respond to changes in the membrane potential of the cell
Voltage Gated Channels
18
Determine what Voltage Gated Mode of Toxin Action: Blocks P-type channel Source: Funnel web spider - Sodium channels: Tetrodotoxin (TTX) - Sodium channels: Batrachotoxin (BTX) - Potassium channels: Apamin - Potassoum channels: Charybdotoxin - Calcium channels: Omega conotoxin - Calcium channels: Agatoxin
Calcium channels: Agatoxin
18
Determine what type of channels: - Would require a chemical ligand to attach to the binding site so that it will be opening or closing the gates so that the specific ion in this channel may be able to go in or out of the neural cell
Ligand Gated Channels
19
Determine what type of channels: - Are exogenous and endogenous chemicals, can mimic the ligand to be able to open ionotropic and metabotropic channels(membrane limited which can affect ion channels) and centers.
Ligand Gated Channels
19
Determine what type of channels: - The opening of this ionic channel would be able to stimulate or inhibit the cells (neuron cells) - Affected by drugs
Ligand Gated Channels

2S - PCT (12 decks)

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