7) Lymphoid Tissues Flashcards
(32 cards)
What term is used to describe T cells that are mature but have not encounter antigens before?
naive
What Ab is expressed by immature B cells?
IgM
What Ab is expressed by mature B cells?
IgM and IgD
immature B cells are also known as what?
self-reactive B cells, meaning they will die if they encounter self antigens
Where will you find double positive T cells?
thymus only
What is also known as thymocyte graveyards?
Hassall’s corpuscles
Where will you find activated B cells in lymph nodes?
secondary follicles
Where will you find resting B cells in lymph nodes?
primary follicles
Where will you find proliferating B cells in lymph nodes?
germinal centers
T cells are found in this region of lymph nodes
paracortex
DCs are found in what areas?
T cell-rich areas
macrophages are found where in lymph nodes?
marginal sinus and medullary cords
How do lymphocytes get back to lymph nodes if it’s only one-way traffic through the lymphatic vessels?
HEVs
When lymphocytes circulate back into the lymph nodes, where do T and B cells go?
T cells remain in the paracortex while B cells must move past these T cells to get to the cortex. This movement of B cells increases the chance of T and B cell interactions
What organ produces the most Abs?
BM because that’s where majority of plasma cells reside
Lymphocytes prefer certain tissues due to adressins
lymphocyte homing
movement between organs provide better chances of encountering antigens
lymphocyte recirculation
Where do memory cells like to hang out? Which lymphoid tissues?
tertiary
APCs found in epidermis are called…
Langerhans cells
Lymph nodes, tonsils, Peyer’s patches, and the spleen are all …
secondary lymphoid tissues
Which lymphoid tissues are comprised mostly of skin and mucosa such as lungs, GI tract, and vagina?
tertiary lymphoid tissues
location where removal of RBCs occur in spleen
red pulp
location where removal of anitgens occur in spleen
PALS
Where are T cells found in spleen?
PALS
