1 - Psychiatry Flashcards

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1
Q

What are the major Mood Disorders?

A
Bipolar Disorders:
-Bipolar I (manic)
-Bipolar II (hyopmanic)
-Cycothymic
-NOS
Depressive (Unipolar) Disorders:
-MDD (single episode, recurrent)
-Dysthymic
-NOS
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2
Q

Describe the following for MDD:

1) clinical presentation
2) epidemiology
3) tx
4) major comobidities

A

MDD: five or more symptoms w/in same 2wk period, one of which is EITHER depressive mood or loss of interest/pleasure

1) Symptoms: Depression, Interest(loss of), Weight change, Sleep, Motor activity, Energy, Guilt, Concentration, Suicide [Depression Is Worth Studiously Memorizing; Extremely Grueling Criteria. Sorry]
- presentation varies w age: 1) Prepuberty: physical complaints, anxiety, agitation; 2) Adolescence: substance abuse, behavioral issues, hygiene issues; 3) Elderly: dementia-like(memory loss, confusion), apathy, weight loss
2) Epidemiology: 17% overall incidence, female:male(2:1), GENETICS, Vulnerability (minority, no social support, low SES), stressor/childhood issues
3) Tx: SSRI, SNRI, TCA, MAOI; CBT, BT, Family Th; ECT(acute)
4) Co’s: Anxiety, Substance abuse(27%), Personality disorders, Eating disorders, Psychosis

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3
Q

Describe the following for Bipolar I:

1) clinical presentation
2) epidemiology
3) tx
4) major comobidities

A

Bipolar I (manic depression): >1wk(less if hospitalized) of “manic” mood; >3 symptoms (4 if only irritable mood)

1) Symptoms: Distractability, Insomnia, Grandiosity, Flight of ideas, increased Activity, pressured Speech, Thoughtlessness/poor judgement/euphoria (DIG FAST)
- CAN have MDE, but NOT req’d
- typically episodic w/ normal function btwn episodes; but Progressive
- HIGH rate of suicide
2) Epidemiology: onset 15-30, GENETICS, women>men
3) Tx:Acute-> anti-psychotics, ECT; Chronic -> Lithium, therapy, antidepressants (worry about forcing into mania)
4) Co’s: Substance Abuse(61%!!),

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4
Q

What is Dysthymic Disorder?

A
  • DD: mood disorder of >2yrs of depressed mood with 2 associated symptoms
  • NO MDE and NO hypomanic episode
  • chronic, light depression that is resistance to Tx
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5
Q

What is Cyclothymic Disorder?

A
  • Mood disorder of >2yrs with numerous periods of hypomanic and depressive SYMPTOMS
  • NO MDE
  • NO hyopmanic episode
  • “Symptom Period” patient is not w/o symptom for >2 mo
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6
Q

What is the benefits of Electroconvulsive Therapy?

A
  • ECT is HIGHLY effective tx for depression and acute manic depression
  • Fastest efficacy
  • used when medications ineffective or there is a need for rapid improvement in symptoms (suicide risk), catatonia
  • avoid if recent MI/Stroke (not absolute contraindication)
  • memory loss is possible
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7
Q

What is Somatization Disorder?

A
  • Somatization DO: hx of physical complaints BEFORE 30y/o occurring over a several year period meeting ALL of the following: 4 pain, 2 GI, 1 sexual, 1 pseudoneurological symptoms (not all at the same time)
  • for ALL of the related symptoms, they EITHER cannot be explained by a medical condition OR the patient’s response is excessive given the extent of the medical indications
  • symptoms are NOT CONSCIOUSLY PRODUCED/FAKED
  • Risk/Prevalence: female>male, frequently a learned affect (family exposure),
  • frequently present as Masochistic -> recount how much they have suffered/sacrificed
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8
Q

What is conversion disorder?

A

1) symptoms affecting voluntary motor/sensory function
2) onset/exacerbation preceded by acute stressor
3) NOT INTENTIONAL PRODUCED/FAKED
4) cannot be explained by medical condition
5) causes clinically significant distress
6) NOT just sex/pain symptoms, NOT somatization
- when the symptom is paralysis = good prognosis, other = bad
- Psychogenic Nonepileptic Seizures -> no prolactin released, no injuries from seizure, fail Hoover’s sign, can respond DURING seizure, no incontinence… mitigate neg effects of seizure

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9
Q

What is Hypochondriasis?

A

1) misinterpretation of symptoms leading to a preoccupation with having/getting sick
2) is NOT delusional, NOT solely concerning appearance(BDD), and NOT resolved by medical testing or advice
3) caused clinically significant distress/impairment
4) >6mo
- NOT INTENTIONALLY PRODUCED/FAKED

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10
Q

What is Body Dysmorphic Disorder?

A
  • preoccupation with physical appearance leads to a clinically significant distress or impairment
  • is able to acknowledge that the concerns are exaggerated, but cannot correct them
  • high suicide rate(20%)
  • may be associated projection, repression, dissociation, distortion
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11
Q

What is Factitious Disorder?

A
  • INTENTIONALLY PRODUCED sickness/symptoms
  • NO external gain (gain = malingering)
  • hx of many tx and px, doctor shopping
  • may have been in the medical field, hold a grudge, been sick recently
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12
Q

What is Factitious Disorder by Proxy?

A

Munchousen’s by proxy

  • make their dependent sick to gain the access to medical tx
  • req’s 15mo to dx
  • parental projection, narcissism, or sadistic impulses
  • hx of sibling death is common
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13
Q

How are somatoform disorders tx?

A

1) Therapy(CBT, BT) -> support reattribution to provide positive explanations for symptoms,
- > set regular appts to reassure them of medical access
- > change + association w/ being sick
2) Meds: SSRI (BBD)

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14
Q

What is General Anxiety Disorder? How is it Tx?

A

GAD
1) excessive worry/anxiety over life event
2) more often than not, lasting >6mo
3) >3: Muscle tension, Fatigue, difficulty Concentration, Restlessness, Irritability, Sleep disturbance {Macbeth Frets Constantly Regarding Illicit Sins}
-Typically a chronic condition if untx
TX: Meds very effective: SSRI, Buspirone (anxiolytic), BZ, Venlafaxine

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15
Q

What is a Panic Attack?

A
  • Discreet period of intense fear in the absence of real danger
  • peaks ~10 min
  • has >4 panic symptoms (ie: dizzy, sweating, chills, tremor, choking, chest pain, shortness of breath, palpitations…)
  • VERY common to go to a general med/specialist before a psych
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16
Q

What is Panic Disorder?

A

1) recurrent unexpected panic attacks
2) at least one of the attacks is followed by >1mo of worrying about another attack
3) NO agoraphobia(social phobia)
4) NOT due to substance abuse, medical condition or other phobia
-> Panic w/ Agoraphobia presents in ~1/2 of panic disorders
-genetic and environmental factors
-Comorbid with depression -> leads to HIGH risk of suicide
TX: SSRI(chronic), BZ (acute), venlafaxine, imipramine
AND CBT

17
Q

What is OCD? How is it Tx?

A

1) EITHER obsession or compulsions are present: Obsession-> recurrent, persistent thoughts or impulses that cannot be represses and that are recognized as a product of their own mind; Compulsion-> repetitive acts/thoughts that are carried out to minimize/correct subject of obsessions
2) Recognized as being inappropriate/excesive
3) cause marked distress, are time consuming (>1hr), interfere with normal routine
4)high comorbidity with depression, tics and tourette’s
5)PANDAS-> OCD in children
TX: SSRI, clomipramine, venlafaxine, AND exposure therapy
-can use surgery, but VERY rare

18
Q

What is a Phobic Disorder? How is Tx?

A

1) irrational fear of some stimulus that results is EITHER disabling avoidance OR anxiety/panic when avoidance is not possible
2) aware fear is unreasonable
Social: fear of embarrassing one-self in public forum
Specific
Agoraphobia: fear of places/situations where escape would prove difficult or embarrassing
TX: B-blockers, SSRI AND BT (exposure), CBT

19
Q

What is Adjustment Disorder? How is it Tx?

A

1) emotional/behavioral response to an identifiable stressor within 3 months of onset of stressor (when removed, sx resolve 6mo (w/ continuous stressor or consequence of stressor)
Tx:
1) symptom based (sleep aid, anxiety, etc)
2) reduce stress: support networks, eduction/de-stigmatize
3) protect from secondary injury (other stressors)

20
Q

What is Acute Stress Disorder? How is Tx?

A

1) precipitating event that threatens life, injury, physical integrity of self or others
2) responds w/ fear, helplessness, or horror
3)Symptom Clusters must have at least:
-1 Reexperiencing
-1 Avoidance
-1 Hyperarousal
-3 Dissociative
4) >2d, <4wks
Tx:
1) watchful waiting: many resolve on their own
2) CBT

21
Q

Describe the symptom clusters of Acute Stress Disorder/PTSD.

A

-Hyperarousal (ASD 1/PTSD 2): difficulty falling asleep, irritability, distracted, hyper-vigilance, exaggerated startle response
-Avoidance(ASD 1/PTSD 3): avoiding thoughts/places/experiences associated with stressor, amnesia, depressive-like symptoms(lack of interest, detachment, restricted range of affect)
Reexperiencing(ASD 1/PTSD 1): recurrent intrusive thoughts/images/perceptions, dreams, flashbacks, distress on Triggers
Dissociative(ASD 3/PTSD 0): sense of numbing, detachment, reduced awareness, derealization(1000yd stare), depersonalization, dissociative amnesia

22
Q

What is PTSD? How is Tx?

A

1) precipitating event that threatens life, injury, physical integrity of self or others
2) responds w/ fear, helplessness, or horror
3)Symptom Clusters must have at least:
-1 Reexperiencing
-2 Hyperarousal
-3 Avoidance
4) >4wks; Acute: 3mo; Delayed: occurring >6mo after event
Tx:
1) Prevention: minimize exposure to trauma, prevent secondary injury (psychological first aid), tx co-morbids,
2) CBT, Stress Inoculation Tng,
3) SSRI, SNRI, mirtazipine/prazosin (nightmares), TCA/MAOI(refractive)
NO Benzodiazipam -> dependence/abuse

23
Q

What are the Dissociative Disorders? What are their major characteristics?

A

1) Depersonalization Do: sense of detachment/removal from oneself that produces distress/impairment
- remains aware of reality (non-psychotic)
2) Dissociative Amnesia: >1 episode of amnesia regarding important information that is too extensive to be explained by normal forgetfulness
- causes significant distress/impairment
3) Dissociative Fugue: sudden, unexpected travel away from home/family loss of one’s identity/past
- assumes new ID
4) Dissociative Identity Disorder: presence of >1 ID/personalities that recurrently take control of behavior
- inability to recall important personal information
- causes significant distress/impairment

24
Q

Describe sleep:

1) states
2) stages
3) rhythms

A

1) 2 states of consciousness: NREM and REM
- REM: Tonic phenomena -> atonia, dreams, penile/clitoris erection; Phasic phenomena-> Rapid eye mvmt, autonomic variability, myoclonic twitches
2) 5 Stages: W, N1, N2, N3, REM
- W: awake-> mostly alpha waves, no eye mvmt, normal muscle tone
- N1: transition-> theta waves(slower/lower freq), slow rolling eye mvmt(SREM),
- N2: sleep spindles/K-complexe, less tone,
- N3:deep sleep-> dominated by delta(slow) waves, no eye mvmt, variable/low tone
- R: REM-> low amplitude w/ sawtooth waves, REMs, atonia
3) 3 Cycles for sleep: ultradian, circadian, and lifetime
- circadian: endogenous rhythm controlled in Suprachiasmatic Nucleus(SCN); can be influenced by light exposure
- ultradian: “sleep cycle” of 90-100min, 3-6 cycles/night, N3 dominate in 1st 2 cycles, REM stages are longer in 2nd 1/2 of night
- life-cycle: general decrease in need for sleep with age; newborn~18hrs, infant~15hrs, kid~10hrs, adult~8hrs, elderly~6

25
Q

What is Insomnia? What the clinical effects? What are the risk factors? Tx?

A
  • Insomnia is a difficulty in initiating and maintaining sleep, resulting in significantly non-restorative sleep and daytime consequences
  • Daytime consequences: fatigue, issues of attention/concentration/memory, irritability, motivaiton, headaches, GI symptoms
  • Risk: increased age, female, stress, ALCOHOL, caffeine, nicotine meds
  • Tx: gold standard=stimulus control, CBT, and relaxation tng
    1) CBT-I-> 4wk program to correct sleep hygiene, reduce hyperarousal, develop coping strategies, re-align expectations
    2) Meds (short term)-> benzodiazepam, ramelteon (melatonin agonist), Z-drugs(zolpidem, zaleplon
  • > if short-acting BZ not effective, work up to intermediate BZ, sedating anti-depressants, etc.
26
Q

What is Sleep Related Breathing Disorder? What are the clinical effects? Tx?

A

-Apnea=cessation of breathing ~10sec
-Obstructive Sleep Apnea: recurrent lapses in laryngeal muscles with continued respiratory effort -> snoring, gasping
-Central Sleep Apnea: repeated periods of insufficient respiration due to a failure in the drive to breath (CNS) -> silent
-HIGHLY under-dx!
-presents are daytime fatigue, morning headaches, depression, nocturia, erectile dysfunction
-CSA can be caused by medications (opioids-> methadone)
-can lead to neurocognitive deficits, HPTN, MI, stroke, CHF, diabetes
Tx: CPAP, behavioral changes (EtOH, cigs,etc), surgery (airway, palate, mandible)

27
Q

What is Narcolepsy? What the clinical effects? What are the risk factors? Tx?

A
  • “can’t stay awake, can’t fall asleep”
  • Narcolepsy is characterized by 1) Excessive Daytime Sleepiness, 2) cataplexy, 3) sleep paralysis, 4) hypnagogic hallucinations
  • Cataplexy: abrupt bilateral loss of skeletal muscle time caused by excited state (laughing, anger, fear, surprise, etc)
  • lose boundary btwn sleep/awake-> manifest REM when awake
  • loss of hypocretin?
  • Dx: EDS >3mo, cataplexy, confirmed by polysonography and/or hypocretin levels
  • Tx: modanafil (EDS), sodium oxybate (GHB/hypnotic), amphetemine (EDS)
  • Combined with behavioral changes -> naps, sleep hygiene, etc
28
Q

What are Circadian Rhythm Sleep Disorders?

A

1) Delayed sleep phase: (primary) late to sleep, late to wake (>2hrs) -> Tx: progressive adjustment of sleep cycle, light therapy, Melatonin
2) Advanced sleep phase: (primary) sleepy early, awake early
3) Jet Lag: (secondary)-> better to go west than east
4) Shift Work (secondary)

29
Q

What are sleep related movement disorders?

A

1) Restless Leg Syndrome-> urge to move leg prior to sleep

2) Periodic Limb Movement in Sleep-> repetitive movement of limb while asleep; can result in arousal

30
Q

What are the core questions to ask when getting a sleep history?

A

BEARS

  • Bedtime-> difficulty getting to sleep, routine
  • EDS-> daytime consequences
  • Awakenings-> early/late phase, nightmares
  • Regularity and duration of sleep-> sleep habits/hygein
  • Snoring-> apnea