PRP

Question 1

Clinical presentation of PRP

Answer 1

small follicular papules, disseminated yellowish to pink scaly plaques surrounding islands of normal skin, and hyperkeratosis of the palms and soles

Question 2

Genetic etiology

Answer 2

Activation (either sporadic or autosomal dominant inheritance) of CARD14 which activates NF-kappaB signaling

Question 3

Five types of PRP

Answer 3

Based on age (I-II in adults and III-V in children). Type IV MCC in pediatrics

Question 4

Treatment

Answer 4

Mild: emolients, topical steroids, keratolytic agents, and tazarotene
Mod-Severe: systemic retinoids are first line
Self-limiting disorder