Natural Killer Cells Flashcards
1
Q
How do NK cells recognize abnormal cells?
A
MHC molecule expression patterns
2
Q
How are tumor cells recognized?
A
failure to express MHC I
3
Q
What are the two types of NK cell receptors?
A
activating receptors
inhibitory receptors
4
Q
When is the “do not kill” signal expressed?
A
normal MHC 1, lack of stress markers
transmitted by inhibitory receptors
5
Q
when is a cell killed?
A
activating receptors: change in MHC 1 expression, stress markers present
6
Q
What is the dominant command of NK cells?
A
inhibitory “do not kill”
