Paracetamol CPG

Question 1

Paracetamol - Presentation

Answer 1

500 mg tablets

120 mg in 5 mL oral liquid (24 mg/mL)

Question 2

Paracetamol - Pharmacology

Answer 2

An analgesic and antipyretic agent

Actions:

• Exact mechanism of action unclear; thought to inhibit prostaglandin synthesis in the CNS

Question 3

Paracetamol - Metabolism

Answer 3

By the liver; excreted by the kidneys

Question 4

Paracetamol - Primary emergency indications

Answer 4

1. Mild pain
2. Headache

Question 5

Paracetamol - Contraindications

Answer 5

1. Hypersensitivity to paracetamol
2. Children < 1 month of age
3. Paracetamol already administered within past 4hrs
4. Total paracetamol intake within past 24hrs exceeding 4 g (adults) or 60 mg/kg (children)
5. Chest pain in suspected acute coronary syndrome

Question 6

Paracetamol - Precautions

Answer 6

1. Impaired hepatic function or liver disease
2. Elderly/frail
3. Malnourished

Question 7

Paracetamol - Route of administration

Answer 7

Oral

Question 8

Paracetamol - Side effects

Answer 8

1. Hypersensitivity reactions including severe skin rashes (rare)
2. Haematological reactions (rare)

Question 9

Paracetamol - Side notes

Answer 9

There are several brands of paracetamol available in Australia. Paracetamol is also found in many combination medicines, both prescription and over the counter. Carefully determine previous Paracetamol intake before dose administration.

The usual dose of Paracetamolfor children is 15 mg/kg per dose. the maximum total dose of 60 mg/kg therefore equates to 4 doses within a 24hr period.

Hepatic damage is very rare when Paracetamol is taken at recommended dosages.

Paracetamol is not indicated for the treatment of fever in the emergency setting.

Onset: 30min

Peak:

Duration: 4hrs