Oncology - Blood Flashcards
A 60-year old smoker with large cervical lymphadenopathy likely has __ and the preferred diagnostic approach is __.
- Squamous cell carcinoma of head/neck
2. Needle biopsy
What are the two categories of lymphoma? Describe cure rates and age of onset.
- Indolent - Incurable, age >40
2. Aggressive - 50% curable, any age
What are B symptoms (3)?
- Weight loss >10% over six months
- Fever >38C
- Recurrent night sweats
What is the difference between Leukemia and Lymphoma?
Leukemia
- neoplastic cells in peripheral blood - neoplastic cells packed in bone marrow
Lymphoma
- neoplastic cells NOT detected in peripheral blood - neoplastic cells confined to lymph nodes and BM
What are three classes of lymphoid malignancies?
- B-Cell
- T-Cell / NK-cell
- Hodgkin’s
What type of blood neoplasm is associated with Helicobacter pylori? What is it also known as?
Gastric MALT (mucosa-associated lymphatic tissue) Lymphoma - AKA Extranodal Marginal-Zone Lymphoma
Follicular Lymphoma
- Indolent or Aggressive
- Treatment options (3)
- Chromosomal rearrangement
- Indolent (70% of all indolent) with aggressive progression 3% year up to 30% in 10 years
- a. Watchful waiting
b. Radiotherapy for Stage I (single lymph node)
c. Rituximab - bcl-2 (t[14;18])
What is the pharmacoodynamics of Rituximab?
Anti-CD20 Monoclonal Antibody
Lymphoplasmacytic Lymphoma
- Indolent or Aggressive
- Hyperviscosity Syndrome
a. Diagnostic lab value
b. Manifestations (3)
c. Treatment (2) - Associated chronic disease
- Eponym
- Indolent
- Serum viscosity > 4 centipoises (ULN 1.8) leads to:
a. Retinopathy with visual blurring
b. CHF
c. Mental status changes- **Treatment = plasmapharesis + Rituximab
- HCV with treatment inducing remission
- Waldenstrom’s Macroglobulinemia
Chronic Lymphocytic Leukemia
- Indolent or Aggressive
- Treatment options (3)
- Lymphomatous counterpart
- Blood smear appearance
- Indolent
- a. Watchful waiting
b. Radiotherapy for Stage I (single lymph node)
c. Rituximab - Small lymphocytic lymphoma
- Smudge cell - bare nucleus
Marginal-Zone B-Cell Lymphoma
- Indolent or Aggressive
- Three types
- Associated chronic disease (2)
- Indolent
- a. Splenic - treat with splenectomy
b. Extranodal MALT - mucosa-associated lymphoid tissue
c. Nodal - HCV and H. pylori - treatment inducing remission
Hairy Cell Leukemia
- Indolent or Aggressive
- Treatment (2)
- Difficulty in work-up?
- Indolent
- Purine analogs: Cladridine or Pentostatin
- Bone marrow fibrotic and not easily aspirated
Mycosis Fungiodes
- Indolent or Aggressive
- Manifestation
- Eponym for advanced stage
- Indolent
- Waxing-waning eczematous plaques
- Sezary syndrome - usually with erythroderma
What is clinically distinct about Hodgkin’s Lymphoma (3)?
- Malignant Reed Sternberg Cells - B cells with bilobed nucleus (like owl’s eye)
- Contiguous disease spread usually from cervical lymph node
- Cure > 75% with chemotherapy with/without radiation
Diffuse Large B-Cell Lymphoma
- Indolent or Aggressive
- Treatment and cure rate
- Relapse treatment
- Aggressive
- R-CHOP with 50% cure
- Stem-cell transplant after re-induction therapy with R-ICE (Rituximab, Ifosfamide, Carboplatin, Etoposide)
A young nonsmoker with large cervical lymphadenopathy likely has __ and the preferred diagnostic approach is __.
- Lymphoma
2. Lymph node excision
Burkitt’s Lymphoma
- Indolent or Aggressive
- Demographics
- Organ involvement
- Lab abnormality
- HIGHLY Aggressive
- Endemic pediatric disease in Africa, contains EBV genome
- Masses involving gastrointestinal tract
- Very high LDH
Mantle Cell Lymphoma
- Indolent or Aggressive
- Cure rate
- Aggressive
2. Incurable after treatment with anthracycline-based chemotherapy