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microbilogy > 4- Virology > Flashcards

4- Virology Flashcards

1
Q

Drug that target viral attachment ? Mechanism of action ? Used to treat ?

A

Maraviroc

CCR5 antagonist

HIV

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2
Q

Drug that target viral penetration ? Mechanism of action ? Used to treat ?

A

Enfuvirtide

Fusion inhibitor

HIV

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3
Q

Drug that target viral uncoating ? Mechanism of action ? Used to treat ?

A

Amantadine / rimantadine

Blocks uncoating via M2 protein

Influenza

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4
Q

Drug that target viral macromolecular synthesis ? Mechanism of action ? Used to treat ?

A

Acyclovir
Zidovudine

Nucleic acid synthesis

Many diseases

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5
Q

Drug that target viral posttranslational modification of proteins ? Mechanism of action ? Used to treat ?

A

Ritonavir

Protease inhibitor

HIV

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6
Q

Drug that target viral release ? Mechanism of action ? Used to treat ?

A

Oseltamivir

Neuraminidase inhibitor

Influenza

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7
Q

Drug that target viral integration ? Mechanism of action ? Used to treat ?

A

Raltegravir

Integrase inhibitor

HIV

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8
Q

Most common vectors for viral spread ?

A

Mosquitos

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9
Q

Target cells Receptor on host cells for HIV ?

A

Th cells
Macrophages
Microglia

CD4 plus CCR5 or CXCR4

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10
Q

Target cells Receptor on host cells for EBV ?

A

B lymphocytes

CD21 = CR2

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11
Q

Target cells Receptor on host cells for Rabies ?

A

Neurons

Ach receptor

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12
Q

Target cells Receptor on host cells for Rhinovirus ?

A

Respiratory epithelial cells

ICAM-1

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13
Q

Ttt of hepatitis C ?

A

Elbasvir / Grazoprevir

Ledipasvir / Sofobuvir

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14
Q

ssDNA virus ?

A

Parvovirus

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15
Q

DNA viruses ?

A 
Pardon Papa As He Has Pox 
Parvovirus 
Papillomavirus , Polyomavirus 
Adenovirus 
Hepadnavirua 
Herpesvirus 
Poxvirus
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16
Q

Major viruses of Herpes virus family ?

A

HSV
Varicella-zoster
Epstein-Barr virus
Cytomegalovirus

17
Q

Major viruses of Poxvirus family ?

A

Variola
Vaccinia
Molluscum contagiosum

18
Q

HPV serotypes that cause common warts ?

A

2 , 4

19
Q

HPV that cause plantar warts ?

A

Serotypes 1

20
Q

HPV serotypes that cause benign anogenital warts ?

A

6 , 11

21
Q

HPV that causes preneoplastic anogenital warts ?

A

16 , 18 ( most common )

31,33,35,45,52,58

22
Q

Ttt of HPV ?

A

Antiviral : cidofovir
Surgical : cryotherapy , laser therapy , excisional
Chemical : podophyllin , trichloroacetic acid , 5-fluorouracil
Immune-mediated : imiquimod , interferon-alpha
Recurrence rates : 30-70% within 6 months

23
Q

Adenovirus serotypes that cause acute respiratory disease ?

A

4 , 7

24
Q

Adenovirus serotypes that cause gastroenteritis ?

A

40 , 41

25
Q

Ttt of adenovirus ?

A

Cidofovir and alpha globulins for severely diseased or immunocompromised

26
Q

Diagnosis of genital Herpes ?

A

Tzank smear

Cowdry type A intranuclear inclusions

27
Q

Mechanism of resistance of HSV to acyclovir ?

A

Mutation in the thymidine kinase which is required to activate the drug

28
Q

Ttt of cytomegalovirus infections ?

A

Ganciclovir / foscarnet +- human immunoglobulins for immunocompromised

29
Q

Mechanism of CMV resistance to Ganciclovir ?

A

Through UL97 gene

30
Q

Which bodies are found intracytoplasmic in Variola/smallpox infections ?

A

Guarnieri bodies

31
Q

Ttt of molluscum contagiosum in immunocompromised patients ?

A

Ritonavir

Cidofovir

32
Q

Naked RNA viruses ?

A

Picornavirus
Calicivirus
Hepevirus
Reovirus

33
Q

Segmented RNA viruses ?

A 
ROBA: 
Reovirus 
Orthomyxovirus 
Bunyavirus 
Arenavirus
34
Q

RNA viruses that carry a virion-associated polymerase ?

A

Reovirus
Arenavirus
Retrovirus

35
Q

+ RNA viruses ?

A 
Call Henry Pico and Flo To Come Rightaway : 
Calicivirus 
Hepevirus 
Picornavirus 
Flavivirus 
Togavirus 
Coronavirus 
Retrovirus
36
Q

Arboviruses ?

A

EEE
WEE
VEE
Chikungunya

37
Q

Second most common cause of common cold ?

A

Coronavirus

microbilogy (6 decks)

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