Neuromuscular Junction Flashcards
How many acetylcholine molecules are needed to open the ligand gated channels?
2
What are some drugs that mimic acetylcholine?
Methacholine, Carbachol and Nicotine
How does Methacholine, Carbachol and Nicotine drugs work?
They are replacement drugs that are can not be broken down by acetylcholinesterase. Do cause spasms
What are examples of inactive acetylcholinesterase drugs?
Neostigmine, physostigmine and diisopropyl fluorophosphates
How do Neostigmine, physostigmine and diisopropyl fluorophosphates work?
Inactivate acetylcholinesterase. Can cause spasms
How do Curare work?
Prevents passages of impulses from nerve endings into muscles.
What is Myasthenia Gravis?
An autoimmune disease that in which antibodies attack acetylcholine receptors. Therefore, end plate potentials are to weak to open voltage gate sodium channels.
Give an example of how Myasthenia Gravis can be resolved for symptom control?
Neostigmine can be used to inactive acetylcholinesterase which will increase chances of A.P