Antiplatelet Drugs and Thrombolytics Flashcards
What are non selective COX inhibitors?
aspirins and NSAIDS
What are selective COX2 inhibitors?
Celecoxib and Celebrex
What are COX3 inhibitors?
Acetaminophen (Tylenol)
What are PDE inhibitors?
dypridamole, and cilostazol
What are P2Y12 platelet receptor inhibitors (ADP receptor Antagonists)?
oral thienopyridines (grels) - Clopidogrel and Prasugrel
What are Gp IIb/IIIa receptor antagonists?
- Synthetic peptides –> eptifibidate
- Antibodies –> abciximab
What are thrombolytic drugs?
streptokinase, urokinase, tPA, reteplase
What are fibrinolytic inhibitors?
Aminocaproic acid
What does inhibition of COX1 in platelets do?
prevents synthesis of Thromboxane
What is aspirin’s MOA? what effect does it have on platelets?
- it acetylates COX-1
- has effect on platelets is 4-7 days, inactivates platelets for their lifetime essentially
- also inhibits COX2 in vascular endothelium to prevent PGI2 formation
What are the side effects of aspirin?
GI bleeding, hemorrhagic stroke, asthma
What is aspirin countraindicated?
courmarin, peptic ulcer disease, and aspirin hypersensitivity
Do NSAIDS have an reversible or irreversible effect on COX1/2?
reversible
Can you aspirins and NSAIDS are the same time?
NOOOO b/c non-selective COX inhibitors compete w/ aspirin for binding to COX.
What COX-2 inhibitor increases coronary heart risk?
Refacoxib – w/drawn from market
