Week 1 formative

Question 1

what disease causes blistering of the back of the hands and excess hair growth (eg on the face)?

Answer 1

PCT (porphyria cutaenea tarda)

Question 2

what cells are responsible for vitamin D metabolism?

Answer 2

keratinocytes

Question 3

what cells are responsible for energy storage?

Answer 3

subcutaneous fat

Question 4

what cells are responsible for epidermal proliferation?

Answer 4

basal cells

Question 5

what cell release inflammatory mediators in the skin?

Answer 5

mast cells

Langerhans are antigen presenting cells

Question 6

what is a main component of a virulent strain of MRSA which causes necrotising fasciitis?

Answer 6

PVL

Panton Valentine Leukocidin

Question 7

Apocrine glands vs Eccrine glands?

Answer 7

apocrine = scent glands
eccrine = moisten hands and feet for grip

Question 8

what is found in the dermis?

Answer 8

fibroblasts
ground substance
lymphatics

Question 9

which enzyme is deficient in acute intermittent porphyria

Answer 9

Porphobilinogin Deaminase (PBG Deaminase)
3rd enzyme in production of haem

Question 10

where are Odland bodies found?

Answer 10

granular layer

Question 11

where are metabolically active cuboidal cells found?

Answer 11

basal layer

Question 12

where are polyhedral cells with lots of desmosomes found?

Answer 12

prickle cell layer

Question 13

what is required to maintain good circulation in the lower limb?

Answer 13

venous valves
muscle pump
pulse pressure

Question 14

how much do finger nails grow per day?

Answer 14

0.1mm

Question 15

painful and slightly red skin on sun exposure but normal on clinical examination?

Answer 15

erythropoetic protoporphyria

Question 16

anagen?
catagen?
telogen?

Answer 16

anagen = growing phase
catagen = involuting phase
telogen = resting phase

Question 17

what are the most common sweat glands on the face?

Answer 17

eccrine sweat glands

Question 18

which enzyme is deficient in erythropoietic protoporphyria?

Answer 18

Ferrochelatase

final enzyme in production of haem

Question 19

where are melanocytes found?

Answer 19

directly above the basal layer which sits on top of the dermo-epidermal junction