Anti-emetics

Question 1

Cyclizine

Answer 1

H1 receptor antagonist.
50mg/8h PO/IV/IM.
For GI causes.

Question 2

Cinnarizine

Answer 2

H1 receptor antagonist.
30mg/8h PO.
For vestibular disorders.

Question 3

Metoclopramide

Answer 3

D2 receptor antagonist.
10mg/8h PO/IV/IM.
For GI causes.
Pro-kinetic.

Question 4

Domperidone

Answer 4

D2 receptor antagonist.
60mg/12h PR, 20mg/6h PO.
Pro-kinetic.

Question 5

Prochlorperazine

Answer 5

D2 receptor antagonist.
12.5mg IM, 5mg/8h PO.
For vestibular/GI causes.

Question 6

Haloperidol

Answer 6

D2 receptor antagonist.
1.5mg/12h PO.
For chemical causes, e.g. opioids.

Question 7

Ondansetron

Answer 7

5HT3 receptor antagonist.

4-8mg/8h IV slowly, doses can be higher for e.g. emetogenic chemotherapy.

Question 8

Hyoscine hydrobromide

Answer 8

200-600mcg SC/IM.

Antimuscarinic, therefore also antispasmodic and antisecretory (don’t prescribe with pro-kinetic).

Question 9

Dexamethasone

Answer 9

6-10mg/d PO/SC.
Unknown mode of action.
Adjuvant.

Question 10

Midazolam

Answer 10

2-4mg/d SC (syringe driver)
Unknown action.
Anti-emetic effect outlasts sedative effect.