Midterm #1 Flashcards
What are the 5 key characteristics of research?
Some Ladies Eat Red Rats
systematic - plan, identify, design, collect data, evaluate logical - examine to evaluate empirical - decisions based on data reductive - general relationships from data replicable - actions recorded and can be repeated
What are the 2 key types of research?
basic and applied
What is basic research?
aims to expand knowledge base by formulating, evaluating, or expanding a theory
discovering knowledge for the sake of knowledge
research in medical science is usually this
What is applied research?
aims to solve practical problems
theoretical concepts tested in real situations
real world is the lab
Why do research?
exploration
- develop ideas on a little understood issue
description
- answer who/what/where/when to paint a picture
explanation
- why things happened
What are some unscientific ways to problem solve?
tradition/tenacity authority figures intuition/common sense media rationalistic method personal experience
What is tenacity/tradition method of problem solving?
clinging to certain beliefs regardless of supporting evidence
“it has always been this way”
What is the authority figures method of problem solving?
overestimate the expertise a famous person of authority has
What is the intuition/common sense method of problem solving?
“it’s true because it makes sense”
valuable in daily living but has serious fallacies
What is the media method of problem solving?
listening to the media, being mislead by visual images
portrayals on TV don’t always reflect the real world
What is the rationalistic method of problem solving?
derive knowledge through reasoning
may not work because statements used in the process could be wrong
What is the personal experience method of problem solving?
“if it happened to me it must be true”
distortion of judgement
What are the 4 errors we make in personal experience problem solving?
selective observations
- observing in a way that reinforces existing thoughts
premature closure
- reaching a decision before achieving the amount of evidence necessary
overgeneralization
- statements that go beyond what can be justified based on data
halo effect
- prior reputations of things colour one’s evaluation
What is a research paradigm/philosophical worldview?
how we look at research
“lens” through which we see the world
a bundle of assumptions about reality that can be used to answer research questions
What are the 2 types of research paradigms?
epistemology and ontology
What is epistemology?
focuses on HOW we acquire knowledge about truth
consists of 3 branches:
positivism, interpretivism, critical realism
What are the branches of epistemology?
positivism
- science based, objective
- can only study what we can measure
- uses observation, measurement, generalization
interpretivism
- subjective
- there are different ways to “know”
- makes no generalizations
- learn to understand the world through other’s eyes
critical realism
- sees reality in terms of observable/tangible sources
- power based
- makes judgements
What is ontology?
focuses on WHAT our belief about the truth is
consists of 2 branches:
objectivism
constructivism
What are the branches of ontology?
objectivism
- study things external to the influence of the researcher
- ex. height
constructivism
- study socially constructed things
- beliefs, behaviours
What is methodology?
how we collect the information we need to answer our research question
What are the 3 main methodologies?
quantitative
- data = numbers
- people being studied = subjects
qualitative
- data = words
- people being studied = participants
mixed methods
- mix of quantitative and qualitative
What is pragmatism?
focused on solutions to problems
not committed to any notion of reality
application focused
What is the transformative worldview?
connected to politics and advocacy
based on reform and change
What is two-eyed seeing?
mutual strengths of knowledge from Indigenous and Western ways of knowing
equity in knowledge
What is ethics?
a set of “right principles”
theory/system of moral values
what we ought to do
What are some examples of unethical studies?
WW2
- frozen to see how long people could survive in freezing water after plane crash
- injected with tetanus, malaria, etc.
Tuskagee Study
- studied African-American population with high rates of syphillis
- believed they responded differently to the disease than other races
- wanted to see long-term effects until death
- not offered treatment when it was discovered
What is a code of ethics?
principles/guidelines developed by professional organizations to guide research practice and clarify the line between ethical and unethical behaviour
2 categories:
scientific dishonesty/academic misconduct
scientific misconduct
What are the categories of a code of ethics?
scientific dishonesty/academic misconduct
- plagiarism
- fabrication
- misleading authorship
- faulty data gathering
scientific misconduct
- failing to protect the rights of participants
- violation of research ethics
What is the Nuremberg Code?
result of Nuremberg Trials
international code of moral and ethical behaviour
10 principles to govern ethical conduct of research involving humans
starting point for systematic protection of humans in all areas of research
What are the flaws of the Nuremberg Code?
too much responsibility given to principle investigator
assumes principle investigator won’t harm the subject
no one to monitor principle investigator and determine if actions are ethical
What is the Declaration of Helsinki?
produced by World Medical Association
founded it’s roots in the Nuremberg Code, but went further and set ethical standards for medical research (specifically experimentation with humans)
What are the CIOMS Guidelines?
Council for International Organizations of Medical Sciences
assists countries in defining national policies of the ethics of biomedical research involving humans
What are 3 National Ethics Review Boards/Committees in Canada?
national research council/medical research council
natural sciences and engineering research council
social sciences and humanities research council
collectively make up the Tri-Council
What are the principles of Canada’s Tri-Council?
A Bear Named Jack
autonomy
- obligation to respect decision making capacities of the autonomous person
beneficence
- obligation to provide benefits and balance benefits against risks
non-maleficence
- obligation to avoid causing harm
justice
- obligation of fairness in distribution of benefits and risks
What is special about Canada’s national research policies?
only country to have a statement acknowledging that studies employing social science methods may require different procedures than those for clinical or intervention studies
What are institutional review boards?
responsible for carrying out policies outlined by Tri-Council
all universities, hospitals have Research Ethics Boards
research cannot be carried out without REB approval
What do REBs review in an ethics application?
risks risks versus benefits subject selection informed consent safety/privacy
as well as professionalism, laws, institution mission
What happens once an ethics application has been reviewed?
it can be approved, disapproved, request for minor modifications, or request for external review
accepted submissions require a yearly review to determine if requested changes have taken place
What is conflict of interest?
reasons why research that is sponsored by a third party may create an ethical conflict
sponsor may :
request suppression of findings tell the researcher what to do
tell researcher what findings they expect
What are the researcher’s main responsibilities?
confidentiality
- ensure all data is kept in confidence/secret from public
- can’t release info that links specific individuals to specific answers
- present aggregate data (as a whole)
debriefing
- explanations provided to the subjects at the end of the study
- reveal any deception
reparation of harm/reinstatement of well-being
- ensure subjects are relieved of any damage or discomfort produced by their participation
What are the rights of the study subjects?
I pick peppers right away
informed consent protection from harm privacy right to withdraw anonymity
What is the principle of voluntary consent?
people should never participate in research unless they explicitly and freely agree to do so
What kind of special populations may lack complete freedom/awareness to give voluntary consent?
youth
incarcerated individuals
people under potential coercion
those with less than full physical, mental, emotional, or other capabilities
What is the dilemma associated with electronic data and health records?
who gets access to what info?
who consents to the distribution of the contents of a person’s medical file?
What is the TCPS 2?
Tri-Council Policy Statement 2nd edition
What are the 3 core principles of the TCPS 2?
respect for persons
- recognizes intrinsic value of humans and the respect/consideration they are due
- obligation to respect autonomy of individuals involved in research
concern for welfare
- concern for a person’s quality of life
- ensuring benefits outweigh risks
justice
- obligation to treat people fairly and equitably
- apply special considerations when working with groups that have been treated unfairly
What is a biohazard?
any organism or it’s derivative that could negatively influence another organism
ex. blood, sweat, saliva
What is the CCAC?
Canadian Council on Animal Care
What is the 3 R’s tenet of the CCAC?
replace
- avoid/replace use of animals whenever possible
reduce
- employ strategies that result in fewer animals being used and which are consistent with sound experimental design
refine
- modify procedures to minimize pain and stress