Translocations/genes (leukemias and lymphomas)

Question 1

Translocation and gene involved with Follicular cell lymphoma?

Answer 1

t(14;18); BCL2 gene overexpression from chromsome 18

Question 2

Translocation and gene involved with Mantle-cell lymphoma?

Answer 2

t(11;14); Cyclin D1 from chromsome 11

Question 3

Translocation and gene involved with diffuse large cell lymphoma

Answer 3

More comon to have abnormalities with overexpression of BCL-6 gene rather than from translocations. If translocations occur, chromsome 3q27-26 is involved

Question 4

Translocation and gene involved with burkitt’s lymphoma?

Answer 4

t(8;14) most common, t(2;8), and t(8;22); c-myc gene from chromosome 8 is involved

Question 5

Mutation involved with small lymphocytic lymphoma?

Answer 5

good: 13q14, bad: trisomy 12

Question 6

Translocation and genes involved with CML?

Answer 6

t(9;22); BCR/ABL gene. ABL from 9, BCR from 22.

Question 7

Translocation involved with CLL?

Answer 7

Same as Small lymphocytic lymphoma;good: 13q14, bad: trisomy 12

Question 8

Translocation and genes involved with AML?

Answer 8

Good: t(15;17);PML/RARa from Acute promyelocytic leukemia/t(8;21), inv(16)
Bad: >5 abnormlaities, deletions of chromosome 5 and 7, 3q abnormalities, 11q23 leukemia

Question 9

Translocation and genes involved with ALL?

Answer 9

Good: hyperdiploid, t(12;21)
Intermediate: t(1;19)
Bad: t(9,22), abn(11q23), hypodiploid, t(4,11) in infants

Question 10

B-cell receptors for small lymphocytic lymphoma?

Answer 10

Co-expression of CD5 and CD23. CD19+, CD20+, CD22+, CD23+, kappa or lambda

Question 11

B-cell receptors for follicular small cleaved lymphoma?

Answer 11

CD19, CD20, CD22, CD10, kappa or lambda chain

Question 12

B-cell receptors for mantle-cell lymphoma?

Answer 12

CD5+ and CD19+. BUT NEGATIVE FOR CD10 and CD23

Question 13

B-cell receptors for Hodgkins lymphoma?

Answer 13

CD15, CD30. BUT NEGATIVE FOR CD45