Body fluids and osmolarity Flashcards

1
Q

where are body fluids found?

A

blood plasma
intracellular
interstitial

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2
Q

how much of body weight is water?

A

60%

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3
Q

how is water content in lean tissue measured

A

L/Kg

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4
Q

how much of total body water content is found in intracellular space?

A

40%

– including blood cells

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5
Q

how much of total body water content is found as interstitial fluid?

A

15%

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6
Q

how much of total body water content is found in plasma space?

A

5%

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7
Q

what makes up the extracellular space?

A

Plasma space and interstitial fluid

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8
Q

how much do blood cells and plasma space make up of the blood volume?

A

8%

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9
Q

what are other fluid compartments found in the body - transcellular fluid?

A
cerebrospinal fluid
aqueous& vitreous humour
synovial fluid
amniotic fluid
GI tract secretions
Lymph fluid
- these spaces are part of the extracellular space
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10
Q

how to measure fluid compartments (volumes) - dilution method?

A
  • Add known amount of substance (in moles) to an unknown volume
  • Measure the concentration (Grams per Litre)
  • Volume = (Amount of Substance (Moles))/(Concentration of substance)
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11
Q

what substances can we use to measure fluid compartments?

A

non Toxic substances
substances that are not metabolised quickly
in the plasma volume somethings that is larges and insoluble as it does not diffuse across capillaries easily
in the extracellular space something that does not enter cells easily

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12
Q

what are the constituents of body fluid?

A

cations and anions - electrolytes
proteins
dissolved gases, nutrients and metabolites
cells in blood

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13
Q

what is osmolarity?

A

concentration of a solution expressed as the total number of solute particles per litre - milliosmoles/L

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14
Q

what is osmolality?

A

concentration of particles per Kg of solution

- milliosmoles/Kg

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15
Q

what are the most abundant ions in body fluids?

A

sodium, chloride and potassium

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16
Q

what should the relative osmolarity of ICF AND ECF be?

A

EQUAL

17
Q

similarities of osmolarity and osmolality?

A

both units of measurements

both measure and calculate osmotic activity

18
Q

how can derive other spaces?

A

interstitial space = extracellular space - plasma volumes

intracellular space = total body of water - extracellular space

19
Q

how many particles in one osmole?

A

1 Osmole = 1 Mole = 6.02 x 1023

20
Q

what is tonicity?

A

Relative concentration of solutes dissolved in solution which determine the direction and extent of diffusion
-Tonicity only applies when solutions are separated by a semi-permeable membrane

21
Q

what is crystalloid pressure?

A

osmotic pressure is due to small diffusible ions

22
Q

why must extra and intracellular osmolarity be equal?

A

as cell membranes are largely impermeable to ions

-ions that are able to cross capillary walls easily show no crystalloid pressue difference

23
Q

what causes some oncotic pressure?

A

A small amount of protein in interstitial fluid

- pressure of around 35mmHg

24
Q

why is oncotic pressure important?

A

for fluid transport across capillaries

25
Q

what is oncotic pressure balanced by?

A

outward hydrostatic pressure

26
Q

what is the total quantity of plasma proteins?

A

70g per litre

27
Q

how much albumin in plasma?

A

48g/L

28
Q

what is albumin important for?

A

transport, buffering

29
Q

how much Alpha, beta and gamma globulins in plasma?

A

0.7-13 g/L

involved in haemostasis

30
Q

how much fibrinogen in plasma?

A

3g/L

31
Q

what is the protein content of interstitial fluid like?

A

low

32
Q

properties of RBC in the plasma

A

main cells in the blood
involved in buffering of blood pH
anaemia = low haemoglobin

33
Q

what is cell ionic composition like?

A
  • fluid contained in cell membranes

- inside cells there is a high conc of K and Mg but LOW Na levels

34
Q

properties of Leucocytes

A

defend against foreign material
inflamm and allergic responses
contain granulocytes, monocytes and lymphocytes

35
Q

properties of platelets

A

central role in haemostasis
no nucleus - contains dense granules
change shape, release granules and stick together when activated