ECT

Question 1

Kindling

Answer 1

ECT does not produce a kindling effect ie repeated seizures lowers seizure threshold

Question 2

BBB permeability

Answer 2

acutely increases after ECT but returns to baseline within 24h

Question 3

EEG

Answer 3

shows delta and theta activity after applying ECT

-pattern returns to normal after 3 months of the end of treatment

Question 4

Neurotrophic factors

Answer 4

increase in NGF, BDNF, NF3

Question 5

Cell growth and synaptic connectivity

Answer 5

increased esp in hippocampus

Question 6

Hormones

Answer 6

• increased cortisol, prolactin, TSH

- vasopressin, ACTH, oxytocin and opioid endorphins also increase consistently

Question 7

Neurotransmitters and their recetors

Answer 7

-5-HT, NA, cholinergic, glutaminergic and GABAergic systems, adenosine A1-receptor and 5-HT2A all decrease in sensitivity