Cytogenetics Flashcards
1
Q
t(14;18)
A
Follicular lymphoma (IgH:Bcl2)
2
Q
t(11;14)
A
Mantle cell lymphoma (cyclin D:IgH)
3
Q
t(8;14)
A
Burkitt Lymphoma (c-myc:IgH)
4
Q
t(2;8)
A
Burkitt Lymphoma
5
Q
t(8;22)
A
Burkitt Lymphoma
6
Q
t(11;18)
A
Marginal zone lymphoma
7
Q
t(9;22)
A
**Philadelphia chromosome, BCR-ABL fusion increases TK activity (CML or poor prognosis B-ALL)
8
Q
t(15;17)
A
AML (specifically APL; retinoic acid receptor disruption) *good prognosis
9
Q
t(8;21)
A
AML *good prognosis
10
Q
inversion 16/t(16;16)
A
AML *good prognosis
11
Q
inversion 3/t(3;3)
A
AML *poor prognosis
12
Q
Monosomy 5
A
MDS or AML with myelodysplasia-related changes *poor prognosis
13
Q
Monosomy 7
A
MDS or AML with myelodysplasia-related changes *poor prognosis
14
Q
t(2;5)
A
Anaplastic large cell lymphoma
15
Q
t(12;21)
A
B-ALL *good prognosis
