The Big Nephron Picture

Question 1

PCT apical transporters.

Answer 1

NaH antiporter

Carbonic anhydride

Question 2

PCT basolateral transporters.

Answer 2

Active Na+ channel

HCO3- Na+ symporter.

Question 3

ALoH apical transporters. Name the diuretic action here.

Answer 3

ROMK

NKCC2 - action of thiazide diuretics.

Question 4

ALoH basolateral transporters.

Answer 4

Na+K+ ATPase.

Question 5

Early DCT apical transporters. Name the diuretic action here.

Answer 5

Na+/2Cl- symporter - thiazide diuretics.

K+ channel

Question 6

Late DCT basolateral transporters

Answer 6

Na+K+ ATPase.

Question 7

Late DCT/CD apical transporters. Name the diuretic action here.

Answer 7

NaH antiporter
Carbonic anhydrase
Na+K+ ATPase
ENaC - amiloride diuretic.

Question 8

Late DCT/CD basolateral transporters. Name the diuretic action here.

Answer 8

Na+K+ ATPase - increased by aldosterone - decreased by aldosterone agonists.
HCO3- Cl- antiporter

Question 9

CD apical transporters.

Answer 9

AQP2

Question 10

CD basolateral transporters

Answer 10

AQP3 and AQP4