moreenuro

Question 1

Selective for Nm nicotininc receptors at NMJ but not autonomic Nn receptors

Answer 1

neuromuscular blocking drugs

Question 2

succinylcholine mechanism:

Answer 2

strong Ach receptor agonist; produces sustained depolarizino and prevents muscle contraction

Question 3

reversal of blockade of succinylcholine phase 1 ((prolonged depolariziation)

Answer 3

no antidote; block potentiated by cholinesterase inhibitors

Question 4

Phase 2 of reversal of blockade

Answer 4

repolarized but blocked; ach receptrs are avialbe but desentized) — may be reversed w cholinesterase inhibitors

Question 5

equal reduciton in Train of 4: in all 4 phases

Answer 5

depolarizing

Question 6

progressive decrease in each of 4 twitches

Answer 6

nondepolarizing

Question 7

nondepoliarizng neuromuscular blocking drugs

Answer 7

tubocurarine, atracurium, mivacurium, pancuronium, vecuronium, rocuronium

Question 8

nondepolarizing mechanism

Answer 8

competitve antagonists: compete with ACh for receptors

Question 9

reversal of blockade for nondepoliarizing drugs

Answer 9

neostigmine (msut be given w atropine to prevent muscarinic effects such as bradycardia), edrophonium, and other cholinesterase inhibtors

Question 10

SE of depolarizing

Answer 10

hypercalcemia, hyperkalemia, malignant hyyperthermia

Question 11

treat malingnat hyperthermia and neuroleptic malignant syndrome

Answer 11

dantrolene

Question 12

mechanism of dantrolene

Answer 12

prevents release of ca2+ from SR of skeletal muscle by binding to ryanodine receptor

Question 13

activates gabaB receptors at spinal cord level, including skeletal muscle relaxation

Answer 13

baclofen

Question 14

treats muscle spasms, MS

Answer 14

baclofen

Question 15

centrally acting skeletal muscle relaxation that treats muscle spasms

Answer 15

cyclobenzamine

Question 16

glaucoma drugs do what

Answer 16

decrease IOP via decrease amt of aqueous humor (inhibit synthesis/secretion or increase drainage)

Question 17

a-agonists

Answer 17

epinephrine, brimonidine

Question 18

a-agonsit that works on a1

Answer 18

epinephrein

Question 19

aagonst that works on a2

Answer 19

brimonidine

Question 20

a-agonists mechanism

Answer 20

decrease aaeuos humor syntehsis via vasoconstriciont (epinephrien)
decrease aqeuos humor synthesis (brimonidine

Question 21

SE of epinephrine

Answer 21

mydriasis (a1): do not use in closed acute angle glaucoma

Question 22

SE of brimonidine (a2)

Answer 22

blurry vision, ocular hyperemia, foreign body sensation, ocular allergic reactions, ocular pruritus

Question 23

B blcokers for glaucoma

Answer 23

timolol, betaxolol, carteolol

Question 24

b blockers do what

Answer 24

decrase aqeous humor synthesis

Question 25

acetazolamdie

Answer 25

decrease acequos humor synthesis via inhbition of carbonic anhdyrase which decreass formation of hco3 in ciliary body, leading to decrease na and fluid transport

Question 26

cholinomimetics (M3)

Answer 26

direct (pilocarpine, carbachol)

indirect (physostigmine, echothiophate)

Question 27

Increase outflow of aqous humor via contraction of ciiliary msucle and opening of trabelcular meshwork

Answer 27

cholinomimetics

Question 28

cholinomimetics se

Answer 28

miosis (contractio nof pupillary sphincter muscles) and cytoplasm (contraction of ciliary muscle)

Question 29

Prostagalndins

Answer 29

bimatoprost, latanoprost (PGF2a)

Question 30

bimatoprost, latanoprost mechanism

Answer 30

increase outflow of aqous humor via decrease resitance of flow through uveoscleral pathway

Question 31

SE of prostaglands: bimatoprost, latanoprost

Answer 31

darkens color of iris (browning), eyelash growth; also pr

Question 32

preferred treamtn of OAG

Answer 32

prostaglandin

Question 33

first line for restless leg syndrome

Answer 33

dopamine agonist (pramiprexole)

Question 34

restless leg syndrome describe

Answer 34

uncomfortable sensation in legs accompanied by urge to move them