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USMLE Step 3 MN > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

List two 1st generation cephalosporins

A
  1. Cefazolin
  2. Cephalexin
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2
Q

List the characteristics of cefazolin

A
  1. Very good for staph & Strep coverage, OK for community GNR
  2. Perfect agent for skin infections, also for community UTIs
  3. Only administered IV
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3
Q

List the characteristics of cephalexin

A
  1. Very good for staph & Strep coverage, OK for community GNR
  2. Perfect agen for skin infections, also for community UTIs
  3. Only administered orally
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4
Q

List 4 2nd generation cephalosporins

A
  1. Cefuroxime
  2. Cefamandole
  3. Cefotetan
  4. Cefoxitin
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5
Q

List the characterisrics of Cefuroxime

A
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6
Q

List the characteristics of Cefamandole

A
  1. 2nd generation cephalosporin
  2. Contains a methylthiotetrazole (MTT) side chain
  3. MTT interfers with vitamin K-dependent y-carboxylation →
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7
Q

List the characteristics of cefotetan

A
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8
Q

List the characteristics of cefoxitin

A
  1. 2nd generation cephalosporin
  2. Loses Staph coverage, good community GNR, but the key is outstanding anaerobic coverage
  3. Lacks MTT moiety
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9
Q

List 5 3rd generation cephalosporins

A
  1. Ceftriaxone
  2. Cefotaxime
  3. Ceftizoxime
  4. Cefixime
  5. Cefepime
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10
Q

List the characteristics of Ceftriaxone

A
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11
Q

List the characteristics of Cefotaxime

A
  1. 3rd generation cephalosporin
  2. Best Strep coverage of all cephalosporins, loses most of Staph coverage, excellent community GNR but no nosocomial GNR coverage
  3. Doses 3X/day (8 hr effect)
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12
Q

List the characteristics of Ceftizoxime

A
  1. 3rd generation cephalosporin
  2. Best Strep coverage of all cephalosporins, loses most of Staph coverage, excellent community GNR but no nosocomial GNR coverage
  3. Doses 3X/day (8 hr effect)
  4. Expanded anaerobic coverage
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13
Q

List the characteristics of Ceftazidime

A
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14
Q

List the characteristics of Cefixime

A
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15
Q

Name an example of 4th generation cephalosporin

A

Cefepime

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16
Q

List the characteristics of Cefepime

A
  1. 4th generation cephalosporin
  2. Remarkably broad spectrum, excellent Staph, Strep, community and nosocomial GNR

USMLE Step 3 MN (33 decks)

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